Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673557 | 0.82 | ACHE (0.46) | MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL6736716 | 0.72 | PTGDR2 (0.39) | PTGDR2MAPTKMT2ALMNAHPGD | |
| SCHEMBL6735126 | 0.72 | MAPT (0.40) | PTGDR2MAPTMEN1KMT2ALMNA | |
| SCHEMBL7670166 | 0.72 | THRB (0.34) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL4395843 | 0.69 | CA12 (0.57) | PTGDR2KMT2ALMNAPTGDR | |
| SCHEMBL7436101 | 0.68 | PTGDR2 (0.48) | PTGDR2MEN1KMT2APTGDR | |
| SCHEMBL7792659 | 0.68 | CA12 (0.56) | PTGDR2LMNAPTGDR | |
| SCHEMBL6740976 | 0.67 | NUDT1 (0.38) | KMT2AALDH1A1 | |
| SCHEMBL22516364 | 0.67 | MEN1 (0.49) | PTGDR2MEN1KMT2APTGDR | |
| SCHEMBL17810318 | 0.67 | KMT2A (0.45) | PTGDR2MAPTMEN1KMT2APTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077969-A1 | BENZOTHIOPHENES, BENZOFURANS, AND INDOLES USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999061435-A1 | BENZOTHIOPHENES, BENZOFURANS, AND INDOLES USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-02 | — | — | WO | disclosed |