Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | RARG | P13631 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5538472 | 0.93 | L3MBTL1 (0.54) | MEN1KMT2AL3MBTL1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL715023 | 0.91 | L3MBTL1 (0.53) | MEN1KMT2AL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL26287992 | 0.90 | L3MBTL1 (0.51) | MEN1KMT2AL3MBTL1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL25310405 | 0.89 | L3MBTL1 (0.50) | MEN1KMT2AL3MBTL1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL8181153 | 0.89 | L3MBTL1 (0.50) | MEN1KMT2AL3MBTL1ALDH1A1MAPK1 | |
| Trifluoroacetic Acid SCHEMBL8438508 | 0.88 | HRH4 (0.45) | MEN1KMT2AL3MBTL1ALDH1A1MAPK1 | |
| Trifluoroacetic Acid SCHEMBL22830136 | 0.85 | ALDH1A1 (0.56) | MEN1KMT2AL3MBTL1ALDH1A1MAPK1 | |
| Trifluoroacetic Acid SCHEMBL2579475 | 0.85 | CYP1A2 (0.49) | MEN1KMT2AL3MBTL1ALDH1A1MAPK1 | |
| Trifluoroacetic Acid SCHEMBL22830205 | 0.81 | ALDH1A1 (0.54) | KMT2AL3MBTL1ALDH1A1MAPK1LMNA | |
| SCHEMBL21386044 | 0.80 | MEN1 (0.53) | MEN1KMT2AL3MBTL1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767800-B1 | HISTIDINE AND HOMOHISTIDINE DERIVATIVES AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER LAMBERT CO (US) | 2001-03-28 | — | — | EP | disclosed |
| EP-0767800-A1 | HISTIDINE AND HOMOHISTIDINE DERIVATIVES AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5571792-A | Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase | WARNER-LAMBERT COMPANY (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996000736-A1 | HISTIDINE AND HOMOHISTIDINE DERIVATIVES AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1996-01-11 | — | — | WO | disclosed |
| US-4460503-A | OLIGO AND POLYPEPTIDES | INSTITUT PASTEUR (FR) | 1984-07-17 | — | — | US | disclosed |