Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.37 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 4/20 | 0.47 |
| ▸ | KDM4A | O75164 | 4/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.45 |
| ▸ | CHAT | P28329 | 3/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631682 | 0.99 | APP (0.46) | APPKDM4AKDM2ACHATINSR | |
| SCHEMBL6711964 | 0.83 | RAB9A (0.49) | APPCHATRAB9AMEN1NPC1 | |
| SCHEMBL28387158 | 0.77 | INSR (0.55) | KDM4AKDM2AINSRCHRM2CHRM4 | |
| SCHEMBL9822952 | 0.77 | INSR (0.55) | KDM4AKDM2AINSRCHRM2CHRM4 | |
| Iodide SCHEMBL8702276 | 0.76 | KDM4A (0.53) | APPKDM4AKDM2AINSRRAB9A | |
| SCHEMBL5712602 | 0.75 | INSR (0.53) | APPKDM4AKDM2AINSRCHRM2 | |
| SCHEMBL5493740 | 0.75 | INSR (0.53) | APPKDM4AKDM2AINSRCHRM2 | |
| Iodide SCHEMBL3954410 | 0.75 | KDM4A (0.56) | APPKDM4AKDM2ACHATINSR | |
| Iodide SCHEMBL187217 | 0.75 | KDM4A (0.56) | APPKDM4AKDM2ACHATINSR | |
| Iodide SCHEMBL554665 | 0.75 | KDM4A (0.56) | APPKDM4AKDM2ACHATINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080110-A2 | USE OF ACTIVATED T CELLS, NERVOUS SYSTEM-SPECIFIC ANTIGENS FOR TREATING DISORDERS OF THE NEVROUS SYSTEM | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999060021-A2 | USE OF ACTIVATED T CELLS, NERVOUS SYSTEM-SPECIFIC ANTIGENS FOR TREATING DISORDERS OF THE NEVROUS SYSTEM | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 1999-11-25 | — | — | WO | disclosed |