Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.54 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TYR | P14679 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | BID | P55957 | 3/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14402389 | 1.00 | LIPG (0.58) | LIPGTAAR1AOC3NR1H2NR1H3 | |
| SCHEMBL19540033 | 1.00 | LIPG (0.58) | LIPGTAAR1AOC3NR1H2NR1H3 | |
| SCHEMBL2584935 | 1.00 | LIPG (0.58) | LIPGTAAR1AOC3NR1H2NR1H3 | |
| SCHEMBL2241863 | 1.00 | LIPG (0.58) | LIPGTAAR1AOC3NR1H2NR1H3 | |
| SCHEMBL19540031 | 1.00 | LIPG (0.58) | LIPGTAAR1AOC3NR1H2NR1H3 | |
| SCHEMBL14402410 | 0.98 | TAAR1 (0.56) | LIPGTAAR1AOC3NR1H2NR1H3 | |
| Ethyne SCHEMBL27743288 | 0.94 | TAAR1 (0.52) | LIPGTAAR1AOC3NR1H2NR1H3 | |
| SCHEMBL1073302 | 0.91 | TAAR1 (0.58) | LIPGTAAR1AOC3CYP3A4TYR | |
| SCHEMBL20382473 | 0.89 | HTR2A (0.52) | LIPGTAAR1AOC3TP53CYP3A4 | |
| Methoxymethane SCHEMBL28252584 | 0.85 | LIPG (0.49) | LIPGTAAR1MEN1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10780092-B2 | Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators | MERCK SHARP & DOHME CORP. (US) | 2020-09-22 | — | — | US | disclosed |
| US-20200216401-A1 | NOVEL SYRINGOLIN ANALOGUES AND METHODS OF MAKING AND USING SAME | UNIV BROWN (US) | 2020-07-09 | — | — | US | disclosed |
| US-20190307753-A1 | FUSED PYRAZINE DERIVATIVES USEFUL AS SOLUBLE GUANYLATE CYCLASE STIMULATORS | MERCK SHARP & DOHME CORP. (US) | 2019-10-10 | — | — | US | disclosed |
| CN-101068774-B | 2-cyclopenten-1-one oxime derivatives inhibiting production of TNF-alpha | AMOREPACIFIC CORP | 2011-08-10 | — | — | CN | disclosed |
| CN-101068774-A | 2-cyclopenten-1-one oxime derivatives inhibiting production of TNF-alpha | AMOREPACIFIC CORP (KR) | 2007-11-07 | — | — | CN | disclosed |
| EP-0851864-B1 | NOVEL COUPLING AGENTS, PROCESSES FOR THEIR PREPARATION AND HAIR DYES | SCHWARZKOPF GMBH HANS (DE) | 2001-05-23 | — | — | EP | disclosed |
| US-5961668-A | 4-(2,4-diaminophenoxymethyl)-1,3-dioxolane secondary intermediates, processes for their production, and hair colorants | HANS SCHWARZKOPF GMBH & CO. KG (DE) | 1999-10-05 | — | — | US | disclosed |
| EP-0851864-A1 | NOVEL COUPLING AGENTS, PROCESSES FOR THEIR PREPARATION AND HAIR DYES | Hans Schwarzkopf GmbH & Co. KG (DE) | 1998-07-08 | — | — | EP | disclosed |
| WO-1997010237-A1 | NOVEL COUPLING AGENTS, PROCESSES FOR THEIR PREPARATION AND HAIR DYES | HANS SCHWARZKOPF GMBH & CO. KG (DE) | 1997-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190307753-A1 | FUSED PYRAZINE DERIVATIVES USEFUL AS SOLUBLE GUANYLATE CYCLASE STIMULATORS | PDE2A, PDE3A, PDE5A | LIPG 2160/4885TAAR1 1129/4885AOC3 3800/4885 |
| US-10780092-B2 | Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators | PDE2A, PDE3A, PDE5A | LIPG 2047/4885TAAR1 1081/4885AOC3 3746/4885 |
| US-20200216401-A1 | NOVEL SYRINGOLIN ANALOGUES AND METHODS OF MAKING AND USING SAME | XIAP, PSMG3, SYVN1 | LIPG 4163/4885TAAR1 4697/4885AOC3 3242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.