SCHEMBL7759044

SCHEMBL7759044

NCCCC[C@H](NC(=O)C1OC1C(=O)Nc1cccc2ccccc12)C(=O)Nc1cccc2ccccc12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NTMT1 Q9BV86 2/20 0.58
HSD17B10 Q99714 1/20 0.47
MC4R P32245 1/20 0.43
MC5R P33032 1/20 0.43
MC3R P41968 1/20 0.43
MC1R Q01726 1/20 0.43
KMT2A Q03164 2/20 0.42
MEN1 O00255 1/20 0.42
PLG P00747 1/20 0.41
KDM4E B2RXH2 4/20 0.41
GAA P10253 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC2 Q92769 1/20 0.41
ANPEP P15144 1/20 0.41
FABP7 O15540 1/20 0.40
CAPN1 P07384 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.39
HDAC4 P56524 1/20 0.39
EP300 Q09472 1/20 0.39
MEF2D Q14814 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8343138 1.00 NTMT1 (0.58) NTMT1HSD17B10MC4RMC5RMC3R
Hydrochloric Acid SCHEMBL8349180 0.99 NTMT1 (0.57) NTMT1HSD17B10MC4RMC5RMC3R
Hydrochloric Acid SCHEMBL7763503 0.99 NTMT1 (0.57) NTMT1HSD17B10MC4RMC5RMC3R
SCHEMBL7762774 0.89 NTMT1 (0.52) NTMT1HSD17B10MC4RMC5RMC3R
Hydrochloric Acid SCHEMBL7764061 0.89 NTMT1 (0.52) NTMT1HSD17B10MC4RMC5RMC3R
Hydrochloric Acid SCHEMBL8345227 0.89 NTMT1 (0.52) NTMT1HSD17B10MC4RMC5RMC3R
SCHEMBL7759003 0.88 NTMT1 (0.53) NTMT1HSD17B10MC4RMC5RMC3R
SCHEMBL8348973 0.88 NTMT1 (0.53) NTMT1HSD17B10MC4RMC5RMC3R
SCHEMBL8349391 0.88 NTMT1 (0.51) NTMT1HSD17B10MC4RMC5RMC3R
SCHEMBL7764063 0.88 NTMT1 (0.51) NTMT1HSD17B10MC4RMC5RMC3R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0808839-B1 EPOXYSUCCINAMIDE DERIVATIVES OR SALTS THEREOF, AND DRUGS CONTAINING THE SAME TAIHO PHARMACEUTICAL CO LTD (JP) 2001-05-23 EP disclosed
US-5883121-A INHIBITING ACTIVITY AGAINST CATHEPSIN, AND IS USEFUL FOR PREVENTION AND TREATMENT OF OSTEOPATHY SUCH AS OSTEOPOROSIS TAIHO PHARMACEUTICAL CO., LTD. (JP) 1999-03-16 US disclosed
EP-0808839-A1 EPOXYSUCCINAMIDE DERIVATIVES OR SALTS THEREOF, AND DRUGS CONTAINING THE SAME TAIHO PHARMACEUTICAL CO., LTD. (JP) 1997-11-26 EP disclosed