SCHEMBL7759671

SCHEMBL7759671

O=C(O)c1ccc(OS(=O)(=O)C(F)(F)F)c(C23CC4CC(CC(C4)C2)C3)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARG P13631 11/20 0.53
RARB P10826 10/20 0.53
RARA P10276 10/20 0.53
MEN1 O00255 3/20 0.53
KMT2A Q03164 3/20 0.53
NR1I2 O75469 1/20 0.53
LMNA P02545 1/20 0.53
PGR P06401 1/20 0.53
HSPD1 P10809 1/20 0.53
GOT1 P17174 1/20 0.53
GLRA1 P23415 1/20 0.53
BLM P54132 1/20 0.53
HSPE1 P61604 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
TP53 P04637 1/20 0.46
CYP3A4 P08684 1/20 0.46
MAPT P10636 1/20 0.46
HPGD P15428 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8765831 0.89 RARG (0.70) RARGRARBRARAMEN1KMT2A
SCHEMBL5887929 0.89 RARA (0.47) RARGRARBRARAMEN1KMT2A
SCHEMBL8658119 0.82 MEN1 (0.64) RARGRARBRARAMEN1KMT2A
SCHEMBL9077071 0.79 RARB (0.63) RARGRARBRARAMEN1KMT2A
SCHEMBL1082340 0.79 RARA (0.77) RARGRARBRARAMEN1KMT2A
SCHEMBL565789 0.79 RARA (0.77) RARGRARBRARAMEN1KMT2A
SCHEMBL28544087 0.79 DRD2 (0.38) KDM4E
Hydrochloric Acid SCHEMBL9124255 0.78 RARA (0.76) RARGRARBRARAMEN1KMT2A
SCHEMBL7689447 0.76 RARB (0.59) RARGRARBRARAMEN1KMT2A
SCHEMBL9318119 0.76 RARB (0.44) RARGRARBRARAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0850909-B1 Stilbene compounds with adamantyl group, compositions containing the same and uses CT INTERNAT DE (FR) 2001-03-21 EP disclosed
EP-0850909-A1 Stilbene compounds with adamantyl group, compositions containing the same and uses CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) 1998-07-01 EP disclosed
EP-0409728-B1 Bi-aromatic esters, process for their preparation and their use in human or animal medicine and in cosmetics CIRD GALDERMA (FR) 1995-03-01 EP disclosed
EP-0409728-A2 Bi-aromatic esters, process for their preparation and their use in human or animal medicine and in cosmetics CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) 1991-01-23 EP disclosed