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Angiotensin Amide

Angiotensin Amide

SCHEMBL7759731

CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C.NC[C@H]1CC[C@H](C(=O)Oc2ccc(CCC(=O)O)cc2)CC1

nearest known ligand 0.62

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Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ AGTR2 P50052 5/20 0.62
▸ AGTR1 P30556 1/20 0.62
▸ REN P00797 2/20 0.57
▸ NPY2R P49146 6/20 0.54
▸ NPY4R P50391 6/20 0.54
▸ NPY5R Q15761 6/20 0.54
▸ NPY1R P25929 4/20 0.54
▸ TFPI P10646 6/20 0.54
▸ RAMP3 O60896 1/20 0.53
▸ CALCR P30988 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Angiotensin Amide SCHEMBL9324 0.90 AGTR2 (0.74) AGTR2AGTR1RENNPY2RNPY4R
Angiotensin Amide SCHEMBL8155919 0.90 AGTR2 (0.74) AGTR2AGTR1RENNPY2RNPY4R
Angiotensin Amide SCHEMBL7337886 0.89 AGTR2 (0.73) AGTR2AGTR1RENNPY2RNPY4R
Angiotensin Amide SCHEMBL9433448 0.89 AGTR2 (0.73) AGTR2AGTR1RENNPY2RNPY4R
Angiotensin Amide SCHEMBL2197068 0.89 AGTR2 (0.73) AGTR2AGTR1RENNPY2RNPY4R
Angiotensin Amide SCHEMBL5722115 0.88 AGTR2 (0.75) AGTR2AGTR1RENNPY2RNPY4R
Angiotensin Amide SCHEMBL10495835 0.88 AGTR2 (0.72) AGTR2AGTR1RENNPY2RNPY4R
Angiotensin Amide SCHEMBL23015107 0.88 AGTR2 (0.71) AGTR2AGTR1RENNPY2RNPY4R
Angiotensin Amide SCHEMBL3850850 0.88 AGTR2 (0.71) AGTR2AGTR1RENNPY2RNPY4R
Angiotensin Ii SCHEMBL513519 0.86 AGTR2 (0.82) AGTR2AGTR1RENNPY2RNPY4R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1086217-A2 NOVEL ANGIOTENSIN RECEPTOR, PRODUCTION AND USE THEREOF Aventis Pharma Deutschland GmbH (DE) 2001-03-28 — — EP disclosed
EP-1086217-A2 NOVEL ANGIOTENSIN RECEPTOR, PRODUCTION AND USE THEREOF Aventis Pharma Deutschland GmbH (DE) 2001-03-28 — — EP disclosed
WO-1999064585-A3 NOVEL ANGIOTENSIN RECEPTOR, PRODUCTION AND USE THEREOF AVENTIS PHARMA GMBH (DE) 2000-04-06 — — WO disclosed
WO-1999064585-A2 NOVEL ANGIOTENSIN RECEPTOR, PRODUCTION AND USE THEREOF AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 1999-12-16 — — WO disclosed
WO-1999064585-A2 NOVEL ANGIOTENSIN RECEPTOR, PRODUCTION AND USE THEREOF AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 1999-12-16 — — WO disclosed