Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Angiotensin Ii. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 3/20 | 0.82 |
| ▸ | AGTR2 | P50052 | 9/20 | 0.82 |
| ▸ | REN | P00797 | 3/20 | 0.64 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.62 |
| ▸ | NPY1R | P25929 | 1/20 | 0.61 |
| ▸ | NPY2R | P49146 | 1/20 | 0.61 |
| ▸ | NPY4R | P50391 | 1/20 | 0.61 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.61 |
| ▸ | ANPEP | P15144 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Angiotensin Ii SCHEMBL13232382 | 0.98 | AGTR2 (0.84) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL1189 | 0.98 | AGTR2 (0.84) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL2566771 | 0.98 | AGTR2 (0.84) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL3465991 | 0.98 | AGTR2 (0.83) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL21267957 | 0.98 | AGTR2 (0.83) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL14990505 | 0.98 | AGTR2 (0.83) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL8898391 | 0.98 | AGTR2 (0.83) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL1585377 | 0.98 | AGTR2 (0.83) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL2183118 | 0.98 | AGTR2 (0.83) | AGTR2AGTR1RENLNPEPANPEP | |
| Angiotensin Ii SCHEMBL21408200 | 0.97 | AGTR2 (0.82) | AGTR2AGTR1RENLNPEPANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104305-B1 | USE OF ANGIOTENSIN IN THE TREATMENT OF CANCER METASTASIS | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2005-03-23 | — | — | EP | claimed |
| CN-115969981-A | Application of beta 3-adrenoceptor agonist in preparation of medicine for preventing or/and treating abdominal aortic aneurysm | 中山大学孙逸仙纪念医院 | 2023-04-18 | — | — | CN | disclosed |
| EP-3525778-A1 | COMBINATION CONTAINING SGC ACTIVATORS AND MINERALOCORTICOID RECEPTOR ANTAGONISTS | Bayer Pharma Aktiengesellschaft (DE) | 2019-08-21 | — | — | EP | disclosed |
| EP-3525779-A1 | COMBINATION CONTAINING SGC STIMULATORS AND MINERALOCORTICOID RECEPTOR ANTAGONISTS | Bayer Pharma Aktiengesellschaft (DE) | 2019-08-21 | — | — | EP | disclosed |
| US-9048195-B2 | Polishing fluid and polishing method | FUJIFILM CORPORATION (JP) | 2015-06-02 | — | — | US | disclosed |
| US-20130164341-A1 | PREPARATION OF FORMULATIONS OF ANGIOTENSIN II AT1 RECEPTORS ANTAGONISTS FOR THE TREATMENT OF ARTERIAL HYPERTENSION, OTHER CARDIOVASCULAR ILLNESSES AND ITS COMPLICATIONS | UNIVERSIDADE FEDERAL DE MINAS GERAIS (BR) | 2013-06-27 | — | — | US | disclosed |
| US-8293723-B2 | Preparation of formulations of angiotensin II AT1 receptors antagonists for the treatment of arterial hypertension, other cardiovascular illnesses and its complications | UNIVERSIDADE FEDERAL DE MINAS GERAIS (BR) | 2012-10-23 | — | — | US | disclosed |
| US-20120028467-A1 | POLISHING FLUID AND POLISHING METHOD | FUJIFILM CORPORATION (JP) | 2012-02-02 | — | — | US | disclosed |
| US-20110091541-A1 | Preparation of formulations of angiotensin II at1 receptors antagonists for the treatment of arterial hypertension, other cardiovascular illnesses and its complications | UNIVERSIDADE FEDERAL DE MINAS GERAIS (BR) | 2011-04-21 | — | — | US | disclosed |
| US-7858597-B2 | Preparation of formulations of angiotensin II AT1 receptors antagonists for the treatment of arterial hypertension, other cardiovascular illnesses and its complications | UNIVERSIDADE FEDERAL DE MIMAS GERAIS - UFMG (BR) | 2010-12-28 | — | — | US | disclosed |
| CN-1523985-B | Preparation of formulations of angiotensin IIAT1 receptors antagonists for the treatment of arterial hypertension, other cardiovascular illnesses and its complications | UNIV MINAS GERAIS | 2010-05-12 | — | — | CN | disclosed |
| US-20080108575-A1 | Preparation of formulations of angiotensin II AT1 receptors antagonists for the treatment of arterial hypertension, other cardiovascular illnesses and its complications | MILLAN RUBEN D S | 2008-05-08 | — | — | US | disclosed |
| US-20040171584-A1 | Preparation of formulations of angiotensin II at1 receptors antagonists for the treatment of arterial hypertension, other cardiovascular illnesses and its complications | UNIVERSIDADE FEDERAL DE MINAS GERAIS - UFMG (BR) | 2004-09-02 | — | — | US | disclosed |
| CN-1523985-A | Preparation of formulations of angiotensin ii at1 receptors antagonists for the treatment of arterial hypertension, other cardiovascular illnesses and its complications | �Ϻ���ͨ��ѧ | 2004-08-25 | — | — | CN | disclosed |
| EP-1389106-A1 | PREPARATION OF FORMULATIONS OF ANGIOTENSIN II AT1 RECEPTORS ANTAGONISTS FOR THE TREATMENT OF ARTERIAL HYPERTENSION, OTHER CARDIOVASCULAR ILLNESSES AND ITS COMPLICATIONS | Universidade Federal de Minas Gerais-Ufmg (BR) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002080910-A1 | PREPARATION OF FORMULATIONS OF ANGIOTENSIN II AT1 RECEPTORS ANTAGONISTS FOR THE TREATMENT OF ARTERIAL HYPERTENSION, OTHER CARDIOVASCULAR ILLNESSES AND ITS COMPLICATIONS | UNIVERSIDADE FEDERAL DE MINAS GERAIS-UFMG (BR) | 2002-10-17 | — | — | WO | disclosed |
| WO-1995011894-A1 | HISTAMINE H3-RECEPTOR ANTAGONISTS AND THERAPEUTIC USES THEREOF | THE UNIVERSITY OF TOLEDO (US) | 1995-05-04 | — | — | WO | disclosed |
| EP-0095584-B1 | SUBSTITUTED 4-PHENOXY AND 4-PHENYLTHIO PROLINES | E.R. Squibb & Sons, Inc. (US) | 1987-01-07 | — | — | EP | disclosed |
| US-4242265-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1980-12-30 | — | — | US | disclosed |