Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 12/20 | 0.54 |
| ▸ | CYP26A1 | O43174 | 8/20 | 0.45 |
| ▸ | CYP26B1 | Q9NR63 | 7/20 | 0.45 |
| ▸ | RARB | P10826 | 6/20 | 0.42 |
| ▸ | RARG | P13631 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | RARA | P10276 | 3/20 | 0.42 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 5/20 | 0.42 |
| ▸ | RXRG | P48443 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7762916 | 0.84 | RXRA (0.53) | RXRACYP26A1CYP26B1RARBRARG | |
| SCHEMBL7756603 | 0.81 | RXRA (0.57) | RXRACYP26A1CYP26B1RARBRARG | |
| SCHEMBL7756598 | 0.78 | RXRA (0.64) | RXRACYP26A1CYP26B1RARBRARG | |
| SCHEMBL7760309 | 0.74 | RXRA (0.56) | RXRACYP26A1CYP26B1RARBRARG | |
| SCHEMBL7760432 | 0.74 | RXRA (0.69) | RXRACYP26A1CYP26B1RARBRARG | |
| SCHEMBL7761565 | 0.73 | CYP26B1 (0.58) | RXRACYP26A1CYP26B1RARBRARG | |
| SCHEMBL7761538 | 0.73 | CYP26B1 (0.58) | RXRACYP26A1CYP26B1RARBRARG | |
| SCHEMBL7882967 | 0.73 | RARB (0.68) | RXRACYP26A1CYP26B1RARBRARG | |
| SCHEMBL7897312 | 0.72 | RXRA (0.53) | RXRACYP26A1CYP26B1RARBRARG | |
| SCHEMBL7760274 | 0.71 | RXRA (0.49) | RXRACYP26A1CYP26B1RARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258775-B1 | 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-07-10 | — | — | US | claimed |
| EP-0915823-B1 | BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES | CT INTERNAT DE (FR) | 2001-04-18 | — | — | EP | claimed |
| US-6258775-B1 | 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-07-10 | — | — | US | disclosed |