Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 1/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19852540 | 0.83 | KCNE1 (0.44) | KCNE1KCNQ1CYP2C9SMN1; SMN2GAA | |
| SCHEMBL6204083 | 0.81 | KCNE1 (0.38) | KCNE1KCNQ1CYP2C9SMN1; SMN2GAA | |
| SCHEMBL28400315 | 0.78 | HTT (0.40) | KCNE1KCNQ1CYP2C9SMN1; SMN2GAA | |
| SCHEMBL3894061 | 0.73 | KCNE1 (0.35) | KCNE1KCNQ1SMN1; SMN2GAAKMT2A | |
| SCHEMBL16291560 | 0.72 | CYP3A4 (0.35) | CYP2C9GAAPKMATMCYP3A4 | |
| Arsenic SCHEMBL8675880 | 0.72 | LMNA (0.34) | KCNE1KCNQ1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL5511497 | 0.70 | KCNE1 (0.37) | KCNE1KCNQ1CYP2C9SMN1; SMN2GAA | |
| SCHEMBL297734 | 0.69 | KCNE1 (0.36) | KCNE1KCNQ1CYP2C9SMN1; SMN2GAA | |
| SCHEMBL27815869 | 0.69 | TRPV1 (0.41) | GAAPKMMEN1KMT2ALMNA | |
| SCHEMBL19839249 | 0.69 | ABCB1 (0.43) | KCNE1KCNQ1CYP2C9GAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1656088-A | Substituted chroman derivatives having cytochrome P450RAI inhibitory activity | ALLERGAN INC (US) | 2005-08-17 | — | — | CN | disclosed |
| CN-1117070-C | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4-tetrahydroquinoline carboxylic acids having retinoid-like biological activity | ALLERGAN SALES INC (US) | 2003-08-06 | — | — | CN | disclosed |
| EP-0876330-B1 | ARYL OR HETEROARYL AMIDES OF TETRAHYDRONAPHTHALENE, CHROMAN, THIOCHROMAN AND 1,2,3,4-TETRAHYDROQUINOLINE CARBOXYLIC ACIDS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES INC (US) | 2001-03-28 | — | — | EP | disclosed |
| CN-1214675-A | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4-tetrahydroquinoline carboxylic acids having retinoid-like biological activity | VISION PHARM LP (US) | 1999-04-21 | — | — | CN | disclosed |