Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | GRIK1 | P39086 | 13/20 | 0.60 |
| ▸ | TRPM4 | Q8TD43 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20455982 | 0.87 | MEN1 (0.74) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL418999 | 0.87 | KDM4E (0.66) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12703526 | 0.85 | MEN1 (1.00) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8483939 | 0.85 | KDM4E (0.72) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7080579 | 0.84 | MEN1 (0.75) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1309256 | 0.83 | MEN1 (0.78) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10501280 | 0.83 | KMT2A (0.68) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7467356 | 0.83 | KMT2A (0.56) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29183052 | 0.82 | GRIK1 (0.68) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13885544 | 0.82 | ALDH1A1 (0.51) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1119338-C | & alpha, -(1-piperazinyl) ocetamido arenecarboxylic acid derivatives as antidiabetic agents | MERCK PATENT GMBH (DE) | 2003-08-27 | — | — | CN | disclosed |
| CN-1301259-A | & alpha, -(1-piperazinyl) ocetamido arenecarboxylic acid derivatives as antidiabetic agents | MERCK PATENT GMBH (DE) | 2001-06-27 | — | — | CN | disclosed |
| EP-1091947-A1 | ALPHA-(1-PIPERAZINYL)ACETAMIDO ARENECARBOXYLIC ACID DERIVATIVES AS ANTIDIABETIC AGENTS | MERCK PATENT GmbH (DE) | 2001-04-18 | — | — | EP | disclosed |
| WO-1999064407-A1 | α-(1-PIPERAZINYL)ACETAMIDO ARENECARBOXYLIC ACID DERIVATIVES AS ANTIDIABETIC AGENTS | MERCK PATENT GMBH (DE) | 1999-12-16 | — | — | WO | disclosed |
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |