SCHEMBL7762277

SCHEMBL7762277

O=C(O)C(CCC(F)(F)F)CCC(F)(F)F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 1/20 0.48
AKR1A1 P14550 1/20 0.48
CHRM3 P20309 1/20 0.48
HTR2A P28223 1/20 0.48
HTR2C P28335 1/20 0.48
ADRA1A P35348 1/20 0.48
HRH1 P35367 1/20 0.48
DRD3 P35462 1/20 0.48
SLC6A3 Q01959 1/20 0.48
HDAC1 Q13547 1/20 0.48
HDAC2 Q92769 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
FOLH1 Q04609 11/20 0.39
CA2 P00918 1/20 0.36
MAPK1 P28482 1/20 0.36
MEN1 O00255 1/20 0.35
GAA P10253 1/20 0.35
KMT2A Q03164 1/20 0.35
CPA1 P15085 1/20 0.34
CPB2 Q96IY4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3904508 0.89 CHRM1 (0.70) CHRM1AKR1A1CHRM3HTR2AHTR2C
SCHEMBL31075345 0.87 SLC1A1 (0.41) CHRM1AKR1A1CHRM3HTR2AHTR2C
SCHEMBL3670846 0.85 FOLH1 (0.58) CHRM1AKR1A1CHRM3HTR2AHTR2C
SCHEMBL28124938 0.85 CA2 (0.61) CHRM1AKR1A1CHRM3HTR2AHTR2C
SCHEMBL5936803 0.82 CHRM1 (0.38) CHRM1AKR1A1CHRM3HTR2AHTR2C
SCHEMBL5385866 0.80 CHRM1 (0.64) CHRM1AKR1A1CHRM3HTR2AHTR2C
SCHEMBL27430163 0.80 ENPEP (0.37) CHRM1AKR1A1CHRM3HTR2AHTR2C
SCHEMBL27237564 0.78 TDP1 (0.39) CHRM1AKR1A1CHRM3HTR2AHTR2C
SCHEMBL5388888 0.77 CHRM1 (0.59) CHRM1AKR1A1CHRM3HTR2AHTR2C
SCHEMBL5387018 0.76 CHRM1 (0.57) CHRM1AKR1A1CHRM3HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1089960-A1 ALPHA-FLUORO ALKYNOIC ACIDS WITH ANTICONVULSANT ACTIVITY AMERICAN BIOGENETIC SCIENCES, INC. (US) 2001-04-11 EP disclosed
EP-1089962-A1 2-FLUORO-2-ALKYL ALKANOAMIDES WITH ANTICONVULSANT ACTIVITY AMERICAN BIOGENETIC SCIENCES, INC. (US) 2001-04-11 EP disclosed
US-6184401-B1 ANTICONVULSANTS,-EPILEPTIC AGENTS; COMPARABLE TO VALPROIC ACID IN THEIR PREVENTION OF SEIZURES BUT HAVE REDUCED TERATOGENIC POTENTIAL, LONGER DURATION OF ACTION AND REDUCED SIDE EFFECTS AMERICAN BIOGENETIC SCIENCES 2001-02-06 US disclosed
WO-1999067195-A1 ALPHA-FLUORO ALKYNOIC ACIDS WITH ANTICONVULSANT ACTIVITY AMERICAN BIOGENETIC SCIENCES INC. (US) 1999-12-29 WO disclosed
WO-1999067199-A1 2-FLUORO-2-ALKYL ALKANOAMIDES WITH ANTICONVULSANT ACTIVITY AMERICAN BIOGENETIC SCIENCES INC. (US) 1999-12-29 WO disclosed