Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17266473 | 0.94 | LTA4H (0.48) | POLBL3MBTL1LTA4HALDH1A1HRH3 | |
| SCHEMBL10002487 | 0.82 | POLB (0.50) | POLBL3MBTL1ALDH1A1HRH3SPHK2 | |
| SCHEMBL7764759 | 0.82 | L3MBTL1 (0.50) | POLBL3MBTL1ALDH1A1HRH3SPHK2 | |
| SCHEMBL2155920 | 0.82 | POLB (0.50) | POLBL3MBTL1ALDH1A1HRH3SPHK2 | |
| SCHEMBL499847 | 0.82 | MEN1 (0.44) | POLBL3MBTL1LTA4HALDH1A1MEN1 | |
| SCHEMBL7764756 | 0.82 | L3MBTL1 (0.50) | POLBL3MBTL1ALDH1A1HRH3SPHK2 | |
| SCHEMBL2185063 | 0.82 | L3MBTL1 (0.50) | POLBL3MBTL1ALDH1A1HRH3SPHK2 | |
| SCHEMBL2185067 | 0.82 | L3MBTL1 (0.50) | POLBL3MBTL1ALDH1A1HRH3SPHK2 | |
| SCHEMBL7764760 | 0.82 | POLB (0.50) | POLBL3MBTL1ALDH1A1HRH3SPHK2 | |
| SCHEMBL28983612 | 0.81 | LTA4H (0.49) | POLBL3MBTL1LTA4HHRH3SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1777427-A | Aminoheteroaryl compounds as protein kinase inhibitors | SUGEN INC (US) | 2006-05-24 | — | — | CN | claimed |
| CN-1777427-A | Aminoheteroaryl compounds as protein kinase inhibitors | SUGEN INC (US) | 2006-05-24 | — | — | CN | disclosed |
| EP-1102789-A1 | MONOCYCLIC COMPOUNDS HAVING NK-2 ANTAGONIST ACTION AND COMPOSITIONS CONTAINING THEM | Menarini Ricerche S.p.A. (IT) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008046-A1 | MONOCYCLIC COMPOUNDS HAVING NK-2 ANTAGONIST ACTION AND COMPOSITIONS CONTAINING THEM | MENARINI RICERCHE S.P.A. (IT) | 2000-02-17 | — | — | WO | disclosed |