Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7763413 | 1.00 | RCE1 (0.46) | RCE1IDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7288005 | 0.80 | RCE1 (0.47) | RCE1IDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7287994 | 0.80 | RCE1 (0.47) | RCE1IDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL17679381 | 0.77 | RCE1 (0.39) | RCE1IDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL11619375 | 0.76 | SLC1A3 (0.43) | RCE1IDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7501665 | 0.76 | SLC1A3 (0.51) | RCE1IDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL9141007 | 0.75 | RCE1 (0.49) | RCE1IDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL9141279 | 0.75 | RCE1 (0.49) | RCE1IDO1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL2453354 | 0.74 | LMNA (0.37) | CYP2D6TSHRALDH1A1LMNA | |
| SCHEMBL8766555 | 0.72 | TSHR (0.68) | IDO1CYP1A2CYP2C19HTTAGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821665-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-1090908-A2 | Cyclobutane derivatives as inhibitors of protein farnesyltransferase | ABBOTT LABORATORIES (US) | 2001-04-11 | — | — | EP | disclosed |
| US-5831115-A | CYCLOBUTANECARBOXAMIDES | ABBOTT LABORATORIES (US) | 1998-11-03 | — | — | US | disclosed |