Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7767000 | 0.90 | KDM4E (0.39) | KDM4EALDH1A1HPGDCA12CA2 | |
| SCHEMBL7767584 | 0.89 | ALK (0.37) | KDM4EALDH1A1HPGDSLC16A3POLB | |
| SCHEMBL7768507 | 0.89 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDSLC16A3NPC1 | |
| SCHEMBL7767002 | 0.82 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDSLC16A3NPC1 | |
| SCHEMBL7769021 | 0.82 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL7767131 | 0.82 | NPC1 (0.37) | KDM4EALDH1A1POLBNPC1RAB9A | |
| SCHEMBL7768555 | 0.78 | ALDH1A1 (0.41) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL7768526 | 0.76 | MAPK14 (0.38) | — | |
| SCHEMBL978583 | 0.75 | KDM4E (0.72) | KDM4EALDH1A1HPGDSLC16A3CA12 | |
| SCHEMBL7767564 | 0.73 | CASP1 (0.43) | KDM4EALDH1A1HPGDGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741128-B1 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | HOFFMANN LA ROCHE (CH) | 2001-06-20 | — | — | EP | disclosed |
| US-5830920-A | PREVENTION GROWTH OF SMOOTH MUSCLE CELLS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0741128-A2 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | F. HOFFMANN-LA ROCHE AG (CH) | 1996-11-06 | — | — | EP | disclosed |