Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 4/20 | 0.34 |
| ▸ | MAOB | P27338 | 4/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7767584 | 0.90 | ALK (0.37) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL7767000 | 0.89 | KDM4E (0.39) | KMT2AMEN1KDM4ERORCALDH1A1 | |
| SCHEMBL7767564 | 0.82 | CASP1 (0.43) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL7763872 | 0.82 | KDM4E (0.42) | NPC1RAB9AKDM4EPOLBMAPT | |
| SCHEMBL7768526 | 0.82 | MAPK14 (0.38) | RORC | |
| SCHEMBL7768507 | 0.79 | ALDH1A1 (0.49) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL7768549 | 0.78 | DRD2 (0.37) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL7763935 | 0.77 | NPC1 (0.42) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL7763882 | 0.76 | ALDH1A1 (0.41) | RAB9AMAPTALDH1A1 | |
| SCHEMBL7763838 | 0.74 | DRD2 (0.43) | NPC1RAB9AMAPTALDH1A1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741128-B1 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | HOFFMANN LA ROCHE (CH) | 2001-06-20 | — | — | EP | disclosed |
| EP-0675145-B1 | Xanthene polymers and copolymers | GEN ELECTRIC (US) | 1998-11-18 | — | — | EP | disclosed |
| EP-0741128-A2 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | F. HOFFMANN-LA ROCHE AG (CH) | 1996-11-06 | — | — | EP | disclosed |
| US-5466777-A | Xanthene polymers, and copolymers, and method for making | GENERAL ELECTRIC COMPANY (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0675145-A2 | Xanthene polymers and copolymers | GENERAL ELECTRIC COMPANY (US) | 1995-10-04 | — | — | EP | disclosed |