Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 10/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30561524 | 0.85 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1640125 | 0.85 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL14878929 | 0.78 | PNMT (0.55) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL8667965 | 0.77 | PNMT (0.49) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL29507804 | 0.77 | DRD2 (0.59) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1953206 | 0.77 | DRD2 (0.59) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1950952 | 0.77 | DRD2 (0.51) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL12004879 | 0.77 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL7763171 | 0.76 | PSEN1 (0.41) | CYP19A1 | |
| SCHEMBL16654227 | 0.75 | PNMT (0.50) | PNMTADRA2AADRA2BADRA2CCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097129-A1 | N-BENZOCYCLOALKYL-AMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | Novartis AG (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-6197798-B1 | INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN | NOVARTIS AG (CH) | 2001-03-06 | — | — | US | disclosed |
| WO-2000005201-A1 | N-BENZOCYCLOALKYL-AMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | NOVARTIS AG (CH) | 2000-02-03 | — | — | WO | disclosed |