Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3039825 | 0.95 | CA2 (0.50) | CA2MAPK1CA1GRIK1GRIK2 | |
| SCHEMBL3034500 | 0.95 | CA2 (0.50) | CA2MAPK1CA1GRIK1GRIK2 | |
| SCHEMBL3034502 | 0.95 | CA2 (0.50) | CA2MAPK1CA1GRIK1GRIK2 | |
| Adipic Acid SCHEMBL28315411 | 0.88 | FFAR4 (0.50) | GPR84 | |
| SCHEMBL6829832 | 0.86 | CA2 (0.47) | CA2MAPK1GRIK1GRIK2SLC1A2 | |
| SCHEMBL6829829 | 0.86 | CA2 (0.47) | CA2MAPK1GRIK1GRIK2SLC1A2 | |
| SCHEMBL6692423 | 0.86 | CA2 (0.47) | CA2MAPK1GRIK1GRIK2SLC1A2 | |
| SCHEMBL973522 | 0.83 | CA2 (0.50) | CA2MAPK1CA1GRIK1GRIK2 | |
| SCHEMBL973520 | 0.83 | CA2 (0.50) | CA2MAPK1CA1GRIK1GRIK2 | |
| SCHEMBL3156057 | 0.80 | CA2 (0.52) | CA2MAPK1CA1GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630472-B1 | THE USE OF AN ION-SELECTIVE POLYMERIC MEMBRANE FOR THE DETECTION OF HEPARIN | UNIV MICHIGAN (US) | 2001-05-02 | — | — | EP | claimed |