SCHEMBL7764577

SCHEMBL7764577

COc1ccccc1OCCN(CCCCC(=O)NC1CCCCC1)Cc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 3/20 0.56
ACHE P22303 3/20 0.56
HPGD P15428 2/20 0.56
ALDH1A1 P00352 2/20 0.56
EPHX1 P07099 1/20 0.53
EPHX2 P34913 2/20 0.51
ICMT O60725 1/20 0.48
ALB P02768 1/20 0.48
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
MAPT P10636 1/20 0.46
BRD4 O60885 1/20 0.46
KMT2A Q03164 3/20 0.45
MEN1 O00255 2/20 0.45
HDAC3 O15379 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC2 Q92769 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8565479 0.86 EPHX1 (0.48) BCHEACHEALDH1A1EPHX1EPHX2
SCHEMBL8022082 0.84 EPHX1 (0.48) BCHEACHEALDH1A1EPHX1EPHX2
SCHEMBL7764563 0.84 LMNA (0.58) BCHEACHEALDH1A1KMT2AMEN1
SCHEMBL7769378 0.83 EPHX1 (0.65) BCHEACHEHPGDALDH1A1EPHX1
SCHEMBL7566432 0.83 EPHX1 (0.65) BCHEACHEHPGDALDH1A1EPHX1
SCHEMBL7568901 0.82 EPHX1 (0.64) BCHEACHEHPGDALDH1A1EPHX1
SCHEMBL7764576 0.82 EPHX1 (0.64) BCHEACHEHPGDALDH1A1EPHX1
SCHEMBL8150113 0.82 HCRTR2 (0.49) BCHEACHEALDH1A1KMT2AMEN1
SCHEMBL7772425 0.82 MEN1 (0.51) BCHEACHEEPHX1EPHX2ICMT
SCHEMBL7568943 0.79 EPHX2 (0.64) HPGDALDH1A1EPHX1EPHX2ICMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0929515-B1 NOVEL PHENOXYETHYLAMINE DERIVATIVES, METHOD OF PREPARATION, APPLICATION AS MEDICINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME CONSEILS DE RECH S SOC D (FR) 2001-06-20 EP disclosed
US-6150417-A ADMINISTERING TO WARM BLOODED ANIMALS COMPOUNDS SUCH AS N-TERT-BUTYL-5-((2-(2-METHOXYPHENOXY)ETHYL)AMINO)PENTANAMIDE FOR INDUCING ANTIEMETIC ACTIVITY; TREATING ANXIETY, DEPRESSION, AND SLEEP DISORDERS SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (FR) 2000-11-21 US disclosed
US-5998666-A ANTIULCER, ANTISECRETORY AGENTS; ANTIEMITIC SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (FR) 1999-12-07 US disclosed