SCHEMBL7764582

SCHEMBL7764582

NC(=O)c1cc(Oc2cccc(N)c2)ccc1N

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.53
ALDH1A1 P00352 3/20 0.53
HDAC3 O15379 3/20 0.50
BRAF P15056 3/20 0.50
HDAC4 P56524 3/20 0.50
HDAC1 Q13547 3/20 0.50
HDAC7 Q8WUI4 3/20 0.50
HDAC2 Q92769 3/20 0.50
HDAC10 Q969S8 3/20 0.50
HDAC11 Q96DB2 3/20 0.50
HDAC8 Q9BY41 3/20 0.50
HDAC6 Q9UBN7 3/20 0.50
HDAC9 Q9UKV0 3/20 0.50
HDAC5 Q9UQL6 3/20 0.50
PARP10 Q53GL7 3/20 0.49
TNKS O95271 1/20 0.49
PARP15 Q460N3 1/20 0.49
PARP14 Q460N5 1/20 0.49
TNKS2 Q9H2K2 1/20 0.49
PARP2 Q9UGN5 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25328315 0.88 NR4A1 (0.52) ALDH1A1HDAC3BRAFHDAC4HDAC1
SCHEMBL31151866 0.88 NR4A1 (0.52) ALDH1A1HDAC3BRAFHDAC4HDAC1
SCHEMBL7761855 0.87 MAOB (0.53) MAOBALDH1A1HDAC3BRAFHDAC4
SCHEMBL2661681 0.87 PARP10 (0.58) MAOBALDH1A1HDAC3BRAFHDAC4
SCHEMBL2949574 0.85 PARP10 (0.59) ALDH1A1HDAC3BRAFHDAC4HDAC1
SCHEMBL6630317 0.80 PARP10 (0.75) MAOBALDH1A1PARP10TNKSPARP15
SCHEMBL9648190 0.79 MAOB (0.59) MAOBALDH1A1ATMMAPTMEN1
SCHEMBL15053820 0.78 PARP10 (0.72) MAOBALDH1A1HDAC8PARP10TNKS
SCHEMBL1553285 0.78 KDM4E (0.55) ALDH1A1HDAC3BRAFHDAC4HDAC1
SCHEMBL7099416 0.77 NR4A1 (0.71) MAOBALDH1A1ATMMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5115089-A Heat resistant polymers for electrical insulation, protective coatings for electronics formed by reaction of tetracarboxylic dianhydrides and diaminoamides and diamines HITACHI CHEMICAL CO., LTD. (JP) 1992-05-19 US claimed
EP-0758665-B1 Polyimides and optical parts obtained by using the same HITACHI CHEMICAL CO LTD (JP) 2001-06-20 EP disclosed
US-5837804-A MULTILAYER POLYIMIDES FOR TRANSPARENCY AND OPTICAL WAVEGUIDES HITACHI CHEMICAL COMPANY, LTD. (JP) 1998-11-17 US disclosed
EP-0758665-A1 Polyimides and optical parts obtained by using the same HITACHI CHEMICAL COMPANY, LTD. (JP) 1997-02-19 EP disclosed
EP-0308270-B1 Processes for preparation of polyimide-isoindoquinazoline dione and precursor thereof HITACHI CHEMICAL CO LTD (JP) 1993-12-08 EP disclosed
US-5115089-A Heat resistant polymers for electrical insulation, protective coatings for electronics formed by reaction of tetracarboxylic dianhydrides and diaminoamides and diamines HITACHI CHEMICAL CO., LTD. (JP) 1992-05-19 US disclosed
EP-0308270-A2 Processes for preparation of polyimide-isoindoquinazoline dione and precursor thereof Hitachi Chemical Co., Ltd. (JP) 1989-03-22 EP disclosed