Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476657 | 0.84 | POLB (0.61) | MEN1KMT2ASCN9AHDAC3HDAC4 | |
| SCHEMBL8889936 | 0.82 | MEN1 (0.60) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL7770299 | 0.80 | MEN1 (0.71) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL7770284 | 0.77 | RORA (0.54) | HSD11B1KDM4ETSHRLMNAHTT | |
| SCHEMBL1093771 | 0.77 | SCN9A (0.56) | SCN9AGLO1 | |
| SCHEMBL31085768 | 0.75 | SCN9A (0.52) | MEN1KMT2ASCN9AHSD11B1MAPT | |
| SCHEMBL28007727 | 0.75 | KDM4E (0.68) | MEN1KMT2AHSD11B1MAPTKDM4E | |
| SCHEMBL5559592 | 0.74 | MAPT (0.53) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL1267178 | 0.73 | ALDH1A1 (0.59) | MEN1KMT2AHSD11B1MAPTKDM4E | |
| SCHEMBL7598878 | 0.72 | PTGES2 (0.62) | MEN1KMT2AHSD11B1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641793-A | POSSESS ENDOTHELIN RECEPTOR ANTAGONIST ACTIVITY; USEFUL IN TREATMENT OF HYPERTENSION, CARDIAC OR CEREBRAL CIRCULATORY DISEASE AND RENAL DISEASE | ZENECA LIMITED (GB) | 1997-06-24 | — | — | US | claimed |
| EP-0682016-A1 | Pyridine derivatives | ZENECA LIMITED (GB) | 1995-11-15 | — | — | EP | claimed |
| EP-0682016-B1 | Pyridine derivatives | ASTRAZENECA AB (SE) | 2001-07-11 | — | — | EP | disclosed |
| US-5641793-A | POSSESS ENDOTHELIN RECEPTOR ANTAGONIST ACTIVITY; USEFUL IN TREATMENT OF HYPERTENSION, CARDIAC OR CEREBRAL CIRCULATORY DISEASE AND RENAL DISEASE | ZENECA LIMITED (GB) | 1997-06-24 | — | — | US | disclosed |
| EP-0682016-A1 | Pyridine derivatives | ZENECA LIMITED (GB) | 1995-11-15 | — | — | EP | disclosed |