Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.55 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29023902 | 0.82 | POLB (1.00) | MEN1KMT2APOLBALDH1A1PKM | |
| SCHEMBL29967435 | 0.82 | POLB (1.00) | MEN1KMT2APOLBALDH1A1PKM | |
| SCHEMBL7764685 | 0.80 | MEN1 (0.67) | MEN1KMT2AALDH1A1HTTHSD11B1 | |
| SCHEMBL30209700 | 0.80 | POLB (0.83) | MEN1KMT2APOLBALDH1A1PKM | |
| SCHEMBL1471970 | 0.80 | POLB (0.76) | MEN1KMT2APOLBALDH1A1PKM | |
| SCHEMBL29227870 | 0.78 | HSD11B1 (0.59) | MEN1KMT2APOLBALDH1A1PKM | |
| SCHEMBL30939457 | 0.78 | HSD11B1 (0.59) | MEN1KMT2APOLBALDH1A1PKM | |
| SCHEMBL9210342 | 0.77 | POLB (0.72) | MEN1KMT2APOLBALDH1A1PKM | |
| SCHEMBL7764513 | 0.75 | EDNRA (0.67) | MEN1KMT2APOLBALDH1A1PKM | |
| SCHEMBL15952993 | 0.75 | ALDH1A1 (0.69) | MEN1KMT2APOLBALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641793-A | POSSESS ENDOTHELIN RECEPTOR ANTAGONIST ACTIVITY; USEFUL IN TREATMENT OF HYPERTENSION, CARDIAC OR CEREBRAL CIRCULATORY DISEASE AND RENAL DISEASE | ZENECA LIMITED (GB) | 1997-06-24 | — | — | US | claimed |
| EP-0682016-A1 | Pyridine derivatives | ZENECA LIMITED (GB) | 1995-11-15 | — | — | EP | claimed |
| EP-0682016-B1 | Pyridine derivatives | ASTRAZENECA AB (SE) | 2001-07-11 | — | — | EP | disclosed |
| US-5641793-A | POSSESS ENDOTHELIN RECEPTOR ANTAGONIST ACTIVITY; USEFUL IN TREATMENT OF HYPERTENSION, CARDIAC OR CEREBRAL CIRCULATORY DISEASE AND RENAL DISEASE | ZENECA LIMITED (GB) | 1997-06-24 | — | — | US | disclosed |
| EP-0682016-A1 | Pyridine derivatives | ZENECA LIMITED (GB) | 1995-11-15 | — | — | EP | disclosed |