Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLA1 | P09884 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3034640 | 0.83 | BRAF (0.52) | HDAC3HDAC1HDAC2HDAC6GRM4 | |
| SCHEMBL14800759 | 0.80 | HDAC3 (0.56) | HDAC3HDAC1HDAC2HDAC6CDK4 | |
| SCHEMBL7981759 | 0.79 | KMT2A (0.63) | GRM4NPSR1KDRMEN1KMT2A | |
| SCHEMBL31220846 | 0.79 | KMT2A (0.63) | GRM4NPSR1KDRMEN1KMT2A | |
| SCHEMBL3584937 | 0.79 | HDAC3 (0.63) | HDAC3HDAC1HDAC2HDAC6CDK4 | |
| SCHEMBL12483125 | 0.78 | POLB (0.57) | HDAC3HDAC1HDAC2HDAC6CDK2 | |
| SCHEMBL12614443 | 0.78 | RAPGEF4 (0.59) | HDAC3HDAC1HDAC2HDAC6MEN1 | |
| SCHEMBL27714382 | 0.77 | SCN9A (0.59) | HDAC3HDAC1HDAC2HDAC6CDK2 | |
| SCHEMBL3951245 | 0.76 | HDAC6 (0.58) | HDAC3HDAC1HDAC2HDAC6GRM4 | |
| SCHEMBL8973728 | 0.76 | NFKB1 (0.57) | HDAC3HDAC1HDAC2HDAC6NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107957-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | claimed |
| WO-2000012485-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | claimed |