Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8004529 | 1.00 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL3656868 | 0.89 | KDM4E (0.44) | KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL7767598 | 0.88 | HSD17B10 (0.43) | PDE4APDE4BPDE4DKDM4EGAA | |
| SCHEMBL8004519 | 0.88 | HSD17B10 (0.43) | PDE4APDE4BPDE4DKDM4EGAA | |
| SCHEMBL12024915 | 0.84 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL30352572 | 0.83 | PDE4B (0.45) | PDE4APDE4BPDE4CPDE4DHTR2A | |
| SCHEMBL22713943 | 0.83 | PDE4B (0.45) | PDE4APDE4BPDE4CPDE4DHTR2A | |
| Ammonia Solution, Strong SCHEMBL8004534 | 0.83 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL7765508 | 0.77 | PDE4B (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7995009 | 0.77 | PDE4B (0.52) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859766-B1 | CHIRAL METHYL PHENYL OXAZOLIDINONES | SCHERING AG (DE) | 2001-05-16 | — | — | EP | disclosed |
| US-6025376-A | INHIBITORS OF TUMOR NECROSIS FACTOR, TREATING MULTIPLE SCLEROSIS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |
| EP-0859766-A1 | CHIRAL METHYL PHENYL OXAZOLIDINONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-26 | — | — | EP | disclosed |
| WO-1997015561-A1 | CHIRAL METHYL PHENYL OXAZOLIDINONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |