Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | FPR2 | P25090 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8004519 | 1.00 | HSD17B10 (0.43) | HSD17B10MAPTPDE4AHPGDPDE4B | |
| SCHEMBL8004529 | 0.88 | PDE4A (0.47) | MAPTPDE4AHPGDPDE4BPDE4D | |
| SCHEMBL7765366 | 0.88 | PDE4A (0.47) | MAPTPDE4AHPGDPDE4BPDE4D | |
| SCHEMBL3656868 | 0.86 | KDM4E (0.44) | HSD17B10KDM4EMEN1ALDH1A1CASP1 | |
| SCHEMBL8229686 | 0.85 | HSD17B10 (0.43) | HSD17B10MAPTPDE4AHPGDPDE4B | |
| Ammonia Solution, Strong SCHEMBL8004523 | 0.84 | PDE4B (0.42) | HSD17B10MAPTPDE4AHPGDPDE4B | |
| SCHEMBL22713943 | 0.81 | PDE4B (0.45) | PDE4APDE4BPDE4DFPR2 | |
| SCHEMBL30352572 | 0.81 | PDE4B (0.45) | PDE4APDE4BPDE4DFPR2 | |
| SCHEMBL6582968 | 0.76 | CASP1 (0.45) | HSD17B10PDE4APDE4BPDE4DCASP1 | |
| SCHEMBL7995009 | 0.75 | PDE4B (0.52) | PDE4APDE4BPDE4DPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859766-B1 | CHIRAL METHYL PHENYL OXAZOLIDINONES | SCHERING AG (DE) | 2001-05-16 | — | — | EP | disclosed |
| US-6025376-A | INHIBITORS OF TUMOR NECROSIS FACTOR, TREATING MULTIPLE SCLEROSIS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |