Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL8004523 | 0.87 | PDE4B (0.42) | PDE4APDE4BPDE4DKDM4EGAA | |
| SCHEMBL8229686 | 0.85 | HSD17B10 (0.43) | PDE4APDE4BPDE4DKDM4EGAA | |
| SCHEMBL12024915 | 0.84 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL4970595 | 0.84 | CA2 (0.46) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL8004529 | 0.83 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL7765366 | 0.83 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL20790227 | 0.78 | MAPT (0.49) | MAPK1TSHRKDM4EGAAMAPT | |
| SCHEMBL12024903 | 0.77 | KDM4E (0.56) | MAPK1TSHRKDM4EGAAMAPT | |
| SCHEMBL2986731 | 0.77 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL19657226 | 0.76 | NR1H4 (0.41) | MAPK1TSHRGAAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025376-A | INHIBITORS OF TUMOR NECROSIS FACTOR, TREATING MULTIPLE SCLEROSIS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |