Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NAAA | Q02083 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7771581 | 0.99 | NPC1 (0.55) | NPC1RECQLRAB9ASMN1; SMN2NAAA | |
| SCHEMBL7769682 | 0.95 | SMN1; SMN2 (0.61) | NPC1RECQLRAB9ASMN1; SMN2NAAA | |
| SCHEMBL7773765 | 0.89 | MGLL (0.50) | NPC1RECQLRAB9ASMN1; SMN2LMNA | |
| SCHEMBL5213750 | 0.88 | NPC1 (0.59) | NPC1RECQLRAB9ASMN1; SMN2NAAA | |
| SCHEMBL7766002 | 0.85 | LMNA (0.58) | NPC1RECQLRAB9ASMN1; SMN2NAAA | |
| SCHEMBL7771582 | 0.84 | LMNA (0.56) | NPC1RECQLRAB9ASMN1; SMN2NAAA | |
| SCHEMBL4921596 | 0.82 | NPC1 (0.59) | NPC1RECQLRAB9ASMN1; SMN2NAAA | |
| SCHEMBL9294010 | 0.81 | NPC1 (0.57) | NPC1RECQLRAB9ASMN1; SMN2NAAA | |
| SCHEMBL7769683 | 0.81 | LMNA (0.64) | NPC1RECQLRAB9ASMN1; SMN2NAAA | |
| SCHEMBL9294218 | 0.81 | NPC1 (0.57) | NPC1RECQLRAB9ASMN1; SMN2NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765879-B1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO CO (JP) | 2001-02-14 | — | — | EP | disclosed |
| US-5861429-A | MITICIDES AND ANTHELMINTICS | SANKYO COMPANY, LIMITED (JP) | 1999-01-19 | — | — | US | disclosed |
| EP-0765879-A1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO COMPANY LIMITED (JP) | 1997-04-02 | — | — | EP | disclosed |