Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | CTSB | P07858 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6538856 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2TSHRALDH1A1KDM4EMAPT | |
| SCHEMBL5804133 | 0.79 | TGFBR1 (0.34) | — | |
| SCHEMBL5804135 | 0.79 | TGFBR1 (0.34) | — | |
| SCHEMBL5674818 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2TSHRALDH1A1KDM4EMAPT | |
| SCHEMBL15502165 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRALDH1A1KDM4EMAPT | |
| SCHEMBL7297298 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHRALDH1A1KDM4EMAPT | |
| SCHEMBL7297292 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHRALDH1A1KDM4EMAPT | |
| SCHEMBL8253529 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2TSHRALDH1A1KDM4EMAPT | |
| SCHEMBL3212391 | 0.73 | CA1 (0.46) | CTSLCTSBCTSSCTSK | |
| SCHEMBL2234718 | 0.73 | MME (0.53) | SMN1; SMN2ALDH1A1LMNAMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100814-A2 | INHIBITORS OF UROKINASE AND BLOOD VESSEL FORMATION | CORVAS INTERNATIONAL, INC. (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000005245-A2 | INHIBITORS OF UROKINASE AND BLOOD VESSEL FORMATION | CORVAS INTERNATIONAL, INC. (US) | 2000-02-03 | — | — | WO | disclosed |