Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7766259 | 0.91 | SMN1; SMN2 (0.51) | SMN1; SMN2JAK1HSD17B10KMT2AALDH1A1 | |
| SCHEMBL7044467 | 0.89 | SMN1; SMN2 (0.49) | SMN1; SMN2JAK1HSD17B10TSHRKMT2A | |
| SCHEMBL7146644 | 0.87 | SMN1; SMN2 (0.53) | SMN1; SMN2HSD17B10KMT2AALDH1A1MAPT | |
| SCHEMBL7767039 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2JAK1KMT2AALDH1A1MAPT | |
| SCHEMBL7044324 | 0.84 | KMT2A (0.46) | SMN1; SMN2HSD17B10TSHRKMT2AALDH1A1 | |
| SCHEMBL7762456 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2JAK1KMT2AMAPTPDE4D | |
| SCHEMBL7765412 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2JAK1KMT2AALDH1A1MAPT | |
| SCHEMBL7766251 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2HSD17B10TSHRMAPTHPGD | |
| SCHEMBL7762520 | 0.81 | JAK2 (0.48) | SMN1; SMN2KMT2AMAPTHPGDMEN1 | |
| SCHEMBL7762515 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2HSD17B10KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |