SCHEMBL7766829

SCHEMBL7766829

C[Si](C)=[Zr](Cc1ccccc1)(Cc1ccccc1)(C1C=Cc2ccccc21)C1C=Cc2ccccc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 6/20 0.38
HTR6 P50406 1/20 0.38
HTR2A P28223 2/20 0.35
KDM4E B2RXH2 2/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
CHRM2 P08172 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CHRM1 P11229 1/20 0.33
DRD2 P14416 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
NFKB1 P19838 1/20 0.33
CHRM3 P20309 1/20 0.33
SLC6A2 P23975 1/20 0.33
HTR2C P28335 1/20 0.33
ADRA1A P35348 1/20 0.33
HRH1 P35367 1/20 0.33
DRD3 P35462 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8755140 0.84 SIGMAR1 (0.35) SIGMAR1HTR6HTR2A
SCHEMBL7774282 0.83 HTR2A (0.38) SIGMAR1HTR6HTR2AKDM4ELMNA
SCHEMBL7772297 0.82 SIGMAR1 (0.36) SIGMAR1HTR6HTR2AKDM4ELMNA
SCHEMBL7627948 0.76 SIGMAR1 (0.38) SIGMAR1HTR6HTR2A
SCHEMBL6362638 0.76 SIGMAR1 (0.38) SIGMAR1HTR6HTR2A
SCHEMBL6909217 0.75 HTR6 (0.33) HTR6HTR2AKDM4ELMNATP53
Hydrochloric Acid SCHEMBL7208821 0.75 SIGMAR1 (0.37) SIGMAR1HTR6HTR2AKDM4EMEN1
SCHEMBL7633058 0.75 SIGMAR1 (0.39) SIGMAR1HTR6HTR2A
SCHEMBL1538971 0.74 HTR2A (0.35) SIGMAR1HTR6HTR2AKDM4ELMNA
SCHEMBL6857144 0.74 HTR2A (0.37) SIGMAR1HTR6HTR2AKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0678530-B1 Process for production of cyclic olefin copolymers and copolymers produced by said process MITSUI CHEMICALS INC (JP) 2001-07-25 EP disclosed
EP-0719803-B1 Process for the production of cycloolefin random copolymer MITSUI CHEMICALS INC (JP) 2001-03-21 EP disclosed
US-5650471-A COPOLYMERIZING AN ALPHA-OLEFIN AND A CYCLOOLEFIN IN THE PRESENCE OF A CATALYST FORMED FROM A TRANSITION METAL COMPOUND AND AN ORGANIC ALUMINUM COMPOUND MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1997-07-22 US disclosed
EP-0768320-A1 Catalyst component and catalyst NIPPON OIL CO. LTD. (JP) 1997-04-16 EP disclosed
US-5559199-A MOLECULAR WEIGHT CONTROL MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1996-09-24 US disclosed
EP-0729983-A2 Process for the production of cycloolefin random copolymer MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1996-09-04 EP disclosed
EP-0719803-A2 Process for the production of cycloolefin random copolymer MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1996-07-03 EP disclosed
EP-0678530-A1 Process for production of cyclic olefin copolymers and copolymers produced by said process MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-10-25 EP disclosed