Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | TSHR | P16473 | 6/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL233721 | 0.95 | LMNA (0.56) | LMNAALDH1A1TSHRTHRBHSD17B10 | |
| Acrylic Acid SCHEMBL8391669 | 0.95 | LMNA (0.56) | LMNAALDH1A1TSHRTHRBHSD17B10 | |
| Acrylic Acid SCHEMBL5826072 | 0.92 | LMNA (0.53) | LMNAALDH1A1TSHRTHRBHSD17B10 | |
| Acrylic Acid SCHEMBL18065812 | 0.88 | LMNA (0.48) | LMNAALDH1A1TSHRTHRBHSD17B10 | |
| Acrylic Acid SCHEMBL1088056 | 0.88 | LMNA (0.48) | LMNAALDH1A1TSHRTHRBHSD17B10 | |
| Ether SCHEMBL6391396 | 0.87 | ALDH1A1 (0.42) | LMNAALDH1A1TSHRTHRBHSD17B10 | |
| Ether SCHEMBL2191778 | 0.87 | ALDH1A1 (0.42) | LMNAALDH1A1TSHRTHRBHSD17B10 | |
| Acrylic Acid SCHEMBL9766440 | 0.86 | LMNA (0.46) | LMNAALDH1A1TSHRTHRBHSD17B10 | |
| Acrylic Acid SCHEMBL4566433 | 0.86 | LMNA (0.46) | LMNAALDH1A1TSHRTHRBHSD17B10 | |
| Acrylic Acid SCHEMBL2305630 | 0.86 | TSHR (0.50) | LMNAALDH1A1TSHRTHRBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001085666-A2 | IMPROVED REFINING PROCESSES | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 2001-11-15 | — | — | WO | disclosed |