Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Acrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.31 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL8391669 | 0.91 | LMNA (0.56) | LMNATSHRALDH1A1HSD17B10ALOX15 | |
| Acrylic Acid SCHEMBL233721 | 0.91 | LMNA (0.56) | LMNATSHRALDH1A1HSD17B10ALOX15 | |
| Acrylic Acid SCHEMBL5826072 | 0.88 | LMNA (0.53) | LMNATSHRALDH1A1HSD17B10ALOX15 | |
| Acrylic Acid SCHEMBL7767285 | 0.86 | LMNA (0.50) | LMNATSHRALDH1A1HSD17B10ALOX15 | |
| Acrylic Acid SCHEMBL18065812 | 0.84 | LMNA (0.48) | LMNATSHRALDH1A1HSD17B10ALOX15 | |
| Acrylic Acid SCHEMBL1088056 | 0.84 | LMNA (0.48) | LMNATSHRALDH1A1HSD17B10ALOX15 | |
| Acrylic Acid SCHEMBL4566433 | 0.82 | LMNA (0.46) | LMNATSHRALDH1A1HSD17B10ALOX15 | |
| Acrylic Acid SCHEMBL2305630 | 0.82 | TSHR (0.50) | LMNATSHRALDH1A1HSD17B10ALOX15 | |
| Acrylic Acid SCHEMBL9299466 | 0.81 | ALDH1A1 (0.50) | LMNATSHRALDH1A1HSD17B10ALOX15 | |
| Acrylic Acid SCHEMBL151092 | 0.80 | LMNA (0.56) | LMNATSHRALDH1A1HSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5053436-A | Hollow acrylate polymer microspheres | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1991-10-01 | — | — | US | disclosed |
| US-5045569-A | Hollow acrylate polymer microspheres | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1991-09-03 | — | — | US | disclosed |