Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13073441 | 0.84 | USP2 (0.39) | USP2SMN1; SMN2EPHX1MAPK1NR1H2 | |
| SCHEMBL2561810 | 0.83 | USP2 (0.41) | USP2SMN1; SMN2EPHX1MAPK1NR1H2 | |
| SCHEMBL27752719 | 0.83 | USP2 (0.41) | USP2SMN1; SMN2EPHX1MAPK1NR1H2 | |
| SCHEMBL28127594 | 0.80 | USP2 (0.42) | USP2SMN1; SMN2EPHX1MAPK1NR1H2 | |
| SCHEMBL28136162 | 0.80 | USP2 (0.42) | USP2SMN1; SMN2EPHX1MAPK1NR1H2 | |
| SCHEMBL27481655 | 0.80 | NR1H2 (0.40) | USP2SMN1; SMN2EPHX1MAPK1NR1H2 | |
| SCHEMBL7367963 | 0.80 | ADRA1D (0.41) | USP2SMN1; SMN2EPHX1MAPK1NR1H2 | |
| SCHEMBL7275829 | 0.80 | ADRA1D (0.41) | USP2SMN1; SMN2EPHX1MAPK1NR1H2 | |
| SCHEMBL19051326 | 0.77 | USP2 (0.40) | USP2SMN1; SMN2EPHX1MAPK1NR1H2 | |
| Piperazine SCHEMBL28853588 | 0.76 | NR1H2 (0.45) | USP2SMN1; SMN2EPHX1MAPK1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0744401-B1 | Process for the preparation of optically active 2-piperazine carboxylic acid derivatives | LONZA AG (CH) | 2001-11-21 | — | — | EP | disclosed |
| EP-1125930-A1 | Optically active piperazine-2-carboxylic acid derivatives and process for their preparation | LONZA AG (CH) | 2001-08-22 | — | — | EP | disclosed |
| EP-0744401-A2 | Process of preparation of optically active 2-piperazine carboxylic acid | LONZA AG (CH) | 1996-11-27 | — | — | EP | disclosed |