SCHEMBL7768248

SCHEMBL7768248

N#Cc1ccc(C[C@H](N)C(=O)O)c(Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.45
USP2 O75604 2/20 0.44
PKM P14618 2/20 0.44
RGS12 O14924 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44
ALOX15 P16050 1/20 0.44
NFKB1 P19838 1/20 0.44
CASP1 P29466 1/20 0.44
BRCA1 P38398 1/20 0.44
THPO P40225 1/20 0.44
CASP7 P55210 1/20 0.44
GNAI1 P63096 1/20 0.44
HIF1A Q16665 1/20 0.44
HSD17B10 Q99714 1/20 0.44
KDM4E B2RXH2 1/20 0.44
MEN1 O00255 1/20 0.44
LMNA P02545 1/20 0.44
POLB P06746 1/20 0.44
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25217534 1.00 ALDH1A1 (0.45) ALDH1A1USP2PKMRGS12CYP3A4
SCHEMBL11114541 0.86 ALDH1A1 (0.48) ALDH1A1KMT2ANPSR1P2RX7
Hydrochloric Acid SCHEMBL25217023 0.81 USP2 (0.46) ALDH1A1USP2PKMRGS12CYP3A4
SCHEMBL44905 0.80 HDAC8 (0.58) ALDH1A1USP2PKMRGS12CYP3A4
SCHEMBL29350881 0.80 HDAC8 (0.58) ALDH1A1USP2PKMRGS12CYP3A4
SCHEMBL44904 0.80 HDAC8 (0.58) ALDH1A1USP2PKMRGS12CYP3A4
SCHEMBL1613174 0.80 HDAC8 (0.58) ALDH1A1USP2PKMRGS12CYP3A4
SCHEMBL2925506 0.78 MPO (0.38) ALDH1A1LMNAPOLBMAPTP2RX7
SCHEMBL5580203 0.78 KMT2A (0.55) ALDH1A1USP2PKMRGS12CYP3A4
SCHEMBL5580201 0.78 KMT2A (0.55) ALDH1A1USP2PKMRGS12CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1115700-A1 OPTICALLY ACTIVE SUBSTITUTED N-ARYL-O-ARYLOXYALKYL-CARBAMATES BAYER AG (DE) 2001-07-18 EP disclosed
WO-2000017157-A1 OPTICALLY ACTIVE SUBSTITUTED N-ARYL-O-ARYLOXYALKYL-CARBAMATES BAYER AKTIENGESELLSCHAFT (DE) 2000-03-30 WO disclosed