Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 known ✓ | P08173 | 2/20 | 0.39 |
| ▸ | EED | O75530 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7764713 | 0.89 | EED (0.51) | EEDMEN1KMT2ACHRM4DRD2 | |
| Cadaverine Tartrate SCHEMBL7765577 | 0.82 | CHRM4 (0.42) | EEDCYP1A2LTB4RLTB4R2MEN1 | |
| SCHEMBL7765574 | 0.75 | FFAR1 (0.41) | MEN1KMT2AFFAR1LMNAALDH1A1 | |
| SCHEMBL5319435 | 0.71 | CHRM4 (0.49) | EEDMEN1KMT2ACHRM4DRD2 | |
| Hydrochloric Acid SCHEMBL5322142 | 0.70 | CHRM4 (0.48) | EEDMEN1KMT2ACHRM4DRD2 | |
| Hydrochloric Acid SCHEMBL27464592 | 0.70 | EED (0.48) | EEDCHRM4DRD2HTR7ALDH1A1 | |
| SCHEMBL7115062 | 0.69 | CHRM4 (0.50) | EEDCHRM4DRD2HTR7ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5319527 | 0.69 | CHRM4 (0.49) | EEDCHRM4DRD2HTR7ALDH1A1 | |
| SCHEMBL20993879 | 0.69 | SLC6A2 (0.47) | CYP1A2MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3154073 | 0.67 | EED (0.63) | EEDMEN1KMT2AGHSRCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842153-B1 | METHOD OF PREPARING NORBENZOMORPHANE AS AN INTERMEDIATE IN THE PREPARATION OF PHARMACEUTICALLY USEFUL BENZOMORPHANE DERIVATIVES, IN PARTICULAR (-)-(1R,5S,2\"R)-3'-HYDROXY-2-(2-METHOXYPROPYL)-5,9,9-TRIMETHYL-6,7-BENZOMORPHANE | BOEHRINGER INGELHEIM PHARMA (DE) | 2001-05-30 | — | — | EP | disclosed |