Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.50 |
| ▸ | MLYCD | O95822 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12631543 | 0.83 | AKR1C3 (0.54) | AKR1C3GPR119MLYCDCCR1MEN1 | |
| SCHEMBL15651967 | 0.81 | GFER (0.58) | POLBMEN1KMT2A | |
| SCHEMBL22495385 | 0.76 | MAPT (0.58) | AKR1C3GPR119POLBMEN1KMT2A | |
| SCHEMBL27643066 | 0.75 | AKR1C3 (0.68) | AKR1C3GPR119SLC6A9CA12CA1 | |
| SCHEMBL3923864 | 0.74 | GPR119 (0.79) | AKR1C3GPR119NAMPTMEN1KMT2A | |
| SCHEMBL28170767 | 0.74 | AKR1C3 (0.58) | AKR1C3GPR119MEN1KMT2A | |
| SCHEMBL12826096 | 0.73 | LMNA (0.59) | AKR1C3GPR119MEN1KMT2A | |
| SCHEMBL16546676 | 0.73 | AKR1C3 (0.50) | AKR1C3GPR119MLYCDMEN1KMT2A | |
| SCHEMBL7764320 | 0.72 | AKR1C3 (0.50) | AKR1C3GPR119MLYCDSLC6A9CYP3A4 | |
| SCHEMBL1970481 | 0.72 | LMNA (0.58) | AKR1C3GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104413-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM | ELI LILLY AND COMPANY LIMITED (GB) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000008006-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM | ELI LILLY AND COMPANY LIMITED (GB) | 2000-02-17 | — | — | WO | disclosed |