Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7769381 | 0.79 | PTGS2 (0.46) | RXRARXRBPTGS2PTGS1HSD17B10 | |
| SCHEMBL5998545 | 0.79 | PTGS1 (0.51) | RXRARXRBTLR7PTGS2PTGS1 | |
| SCHEMBL601281 | 0.76 | HSD17B10 (0.54) | RXRARXRBPTGS2PTGS1HSD17B10 | |
| SCHEMBL7457755 | 0.72 | TLR7 (0.38) | TLR7PTGS2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL601277 | 0.69 | CYP3A4 (0.43) | TLR7PTGS2PTGS1CYP2C19CYP3A4 | |
| SCHEMBL11274411 | 0.68 | ESR1 (0.39) | ESR1CYP2C19HSD17B10MEN1KMT2A | |
| SCHEMBL603692 | 0.66 | HSP90AA1 (0.44) | TLR7CYP2C19CYP3A4CYP2D6TSHR | |
| SCHEMBL12764023 | 0.66 | ESR1 (0.45) | ESR1TSHRLMNAMEN1KMT2A | |
| SCHEMBL31347570 | 0.66 | NT5E (0.37) | CYP2C19CYP3A4CYP2D6TSHRCRHBP | |
| SCHEMBL26987221 | 0.66 | NT5E (0.37) | CYP2C19CYP3A4CYP2D6TSHRCRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798297-B1 | Process for the preparation of 2-alkoxy-6-(trifluoromethyl)-pyrimidine-4-ol | LONZA AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-5717096-A | Process for the preparation of a 2-alkoxy-6-(trifluoromethyl)pyrimidin-4-ol | LONZA AG (CH) | 1998-02-10 | — | — | US | disclosed |
| EP-0798297-A1 | Process for the preparation of 2-alkoxy-6-(triflourmethyl)-pyrimidin-4-ol | LONZA AG (CH) | 1997-10-01 | — | — | EP | disclosed |