Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | RXRA | P19793 | 3/20 | 0.42 |
| ▸ | RXRB | P28702 | 3/20 | 0.42 |
| ▸ | RXRG | P48443 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30657772 | 0.82 | LTA4H (0.38) | PTGS2PTGS1HSD17B10ALDH1A1MAPT | |
| SCHEMBL7769189 | 0.79 | ESR1 (0.40) | PTGS2PTGS1RXRARXRBHSD17B10 | |
| SCHEMBL601281 | 0.78 | HSD17B10 (0.54) | PTGS2PTGS1RXRARXRBHSD17B10 | |
| SCHEMBL5998545 | 0.73 | PTGS1 (0.51) | PTGS2PTGS1RXRARXRBHSD17B10 | |
| SCHEMBL17584792 | 0.73 | LTA4H (0.41) | PTGS2PTGS1ALDH1A1MAPTMEN1 | |
| SCHEMBL9519023 | 0.73 | CYP2C19 (0.35) | HSP90AA1HSP90AB1ALDH1A1MAPTMEN1 | |
| SCHEMBL9843933 | 0.70 | GPR84 (0.37) | PTGS2PTGS1HSP90AA1HSP90AB1HPGD | |
| SCHEMBL7776188 | 0.69 | MEN1 (0.39) | PTGS2PTGS1HSD17B10ALDH1A1MAPT | |
| SCHEMBL19510618 | 0.68 | FFAR4 (0.41) | PTGS2PTGS1FFAR4ALDH1A1MAPT | |
| SCHEMBL603692 | 0.67 | HSP90AA1 (0.44) | HSD17B10HSP90AA1HSP90AB1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798297-B1 | Process for the preparation of 2-alkoxy-6-(trifluoromethyl)-pyrimidine-4-ol | LONZA AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-5717096-A | Process for the preparation of a 2-alkoxy-6-(trifluoromethyl)pyrimidin-4-ol | LONZA AG (CH) | 1998-02-10 | — | — | US | disclosed |
| EP-0798297-A1 | Process for the preparation of 2-alkoxy-6-(triflourmethyl)-pyrimidin-4-ol | LONZA AG (CH) | 1997-10-01 | — | — | EP | disclosed |