Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.44 |
| ▸ | RXRB | P28702 | 9/20 | 0.44 |
| ▸ | RXRG | P48443 | 6/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 5/20 | 0.39 |
| ▸ | DRD5 | P21918 | 5/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | BAD | Q92934 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30974571 | 0.87 | ALDH1A1 (0.54) | RXRARXRBRXRGMRGPRX4ALDH1A1 | |
| SCHEMBL7770798 | 0.87 | ALDH1A1 (0.54) | RXRARXRBRXRGMRGPRX4ALDH1A1 | |
| SCHEMBL9536348 | 0.84 | ALDH1A1 (0.54) | RXRARXRBRXRGMRGPRX4ALDH1A1 | |
| SCHEMBL9311184 | 0.80 | ALDH1A1 (0.56) | RXRARXRBRXRGMRGPRX4ALDH1A1 | |
| SCHEMBL11875425 | 0.73 | ALDH1A1 (0.49) | ALDH1A1GLATP53CYP3A4TSHR | |
| SCHEMBL11514478 | 0.72 | ALDH1A1 (0.47) | ALDH1A1GLATP53CYP3A4TSHR | |
| SCHEMBL7964625 | 0.71 | ALDH1A1 (0.59) | RXRARXRBRXRGALDH1A1TP53 | |
| SCHEMBL7964624 | 0.71 | ALDH1A1 (0.59) | RXRARXRBRXRGALDH1A1TP53 | |
| SCHEMBL3133660 | 0.71 | ALDH1A1 (0.59) | RXRARXRBRXRGALDH1A1TP53 | |
| SCHEMBL3848803 | 0.71 | ALDH1A1 (0.49) | MRGPRX4ALDH1A1GLATP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114029-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000015614-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-23 | — | — | WO | disclosed |