Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | RXRB | P28702 | 9/20 | 0.48 |
| ▸ | RXRA | P19793 | 9/20 | 0.48 |
| ▸ | RXRG | P48443 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7770798 | 0.97 | ALDH1A1 (0.54) | ALDH1A1GLATP53CYP3A4TSHR | |
| SCHEMBL30974571 | 0.97 | ALDH1A1 (0.54) | ALDH1A1GLATP53CYP3A4TSHR | |
| SCHEMBL9311184 | 0.92 | ALDH1A1 (0.56) | ALDH1A1GLATP53CYP3A4TSHR | |
| SCHEMBL7769212 | 0.84 | RXRA (0.44) | ALDH1A1GLATP53CYP3A4TSHR | |
| SCHEMBL11090866 | 0.81 | ALDH1A1 (0.48) | ALDH1A1GLATP53CYP3A4TSHR | |
| SCHEMBL21254625 | 0.81 | HTR2A (0.66) | CYP3A4RXRBRXRARXRGHTR2A | |
| SCHEMBL8432284 | 0.81 | HTR2A (0.66) | CYP3A4RXRBRXRARXRGHTR2A | |
| SCHEMBL11514478 | 0.80 | ALDH1A1 (0.47) | ALDH1A1GLATP53CYP3A4TSHR | |
| SCHEMBL9323483 | 0.79 | ALDH1A1 (0.53) | ALDH1A1GLATP53CYP3A4TSHR | |
| SCHEMBL8051434 | 0.79 | MRGPRX4 (0.52) | ALDH1A1GLATP53CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254595-A | Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them | ELF SANOFI (FR) | 1993-10-19 | — | — | US | disclosed |
| EP-0375560-B1 | ARYLOXYPROPANOLAMINOTETRALINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ELF SANOFI (FR) | 1993-05-12 | — | — | EP | disclosed |
| EP-0375560-A1 | Aryloxypropanolaminotetralines, process for their preparation and pharmaceutical compositions containing same | ELF SANOFI (FR) | 1990-06-27 | — | — | EP | disclosed |