Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11525661 | 0.64 | KMT2A (0.41) | KMT2AGPR139RAB9ANPC1ALDH1A1 | |
| SCHEMBL2774081 | 0.62 | NPC1 (0.44) | KMT2ARAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL9032933 | 0.62 | KDM4E (0.34) | KMT2AGPR139ACERAB9ANPC1 | |
| SCHEMBL9031327 | 0.62 | KDM4E (0.34) | KMT2AGPR139ACERAB9ANPC1 | |
| SCHEMBL7766834 | 0.61 | CYP2C19 (0.40) | KMT2AALDH1A1 | |
| SCHEMBL9301261 | 0.60 | KMT2A (0.44) | KMT2AGPR139RAB9ANPC1ALDH1A1 | |
| SCHEMBL1356205 | 0.60 | TSHR (0.41) | KMT2ARAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL17236360 | 0.59 | KMT2A (0.46) | KMT2AGPR139RAB9ANPC1ALDH1A1 | |
| SCHEMBL7436212 | 0.59 | KMT2A (0.46) | KMT2AGPR139RAB9ANPC1ALDH1A1 | |
| SCHEMBL8311878 | 0.59 | KMT2A (0.46) | KMT2AGPR139RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639566-B1 | CYCLIC COMPOUND | SANTEN PHARMACEUTICAL CO LTD (JP) | 2001-06-20 | — | — | EP | disclosed |
| US-5461158-A | Immunodeficiency and autoimmune diseases | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| EP-0639566-A1 | CYCLIC COMPOUND | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-02-22 | — | — | EP | disclosed |