Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7771319 | 0.86 | HDAC3 (0.48) | ALDH1A1CES1CES2KDM4EMAPT | |
| SCHEMBL7771569 | 0.81 | KDM4E (0.41) | ALDH1A1KDM4EFAAHMAPTKMT2A | |
| SCHEMBL7769673 | 0.81 | KDM4E (0.41) | ALDH1A1KDM4EMAPTKMT2APOLB | |
| SCHEMBL7765971 | 0.79 | THRB (0.40) | ALDH1A1HSP90AA1KDM4EFAAHMAPT | |
| SCHEMBL20991863 | 0.78 | ALDH1A1 (0.49) | ALDH1A1HSP90AA1CES1CES2KDM4E | |
| SCHEMBL135436 | 0.77 | — | — | |
| SCHEMBL17570456 | 0.75 | ALDH1A1 (0.67) | ALDH1A1HSP90AA1KDM4EMAPTKMT2A | |
| SCHEMBL17570455 | 0.75 | KDM4E (0.47) | ALDH1A1KDM4EMAPTKMT2APOLB | |
| SCHEMBL7769845 | 0.75 | FAAH (0.46) | ALDH1A1HSP90AA1CES1CES2KDM4E | |
| SCHEMBL7769860 | 0.75 | ALDH1A1 (0.40) | ALDH1A1HSP90AA1CES1CES2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765879-B1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO CO (JP) | 2001-02-14 | — | — | EP | disclosed |
| US-5861429-A | MITICIDES AND ANTHELMINTICS | SANKYO COMPANY, LIMITED (JP) | 1999-01-19 | — | — | US | disclosed |
| EP-0765879-A1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO COMPANY LIMITED (JP) | 1997-04-02 | — | — | EP | disclosed |