Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 7/20 | 0.34 |
| ▸ | CTSS | P25774 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.32 |
| ▸ | CAD | P27708 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 3/20 | 0.32 |
| ▸ | Q9HBH1 | 1/20 | 0.32 | |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSH | P09668 | 1/20 | 0.32 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3805990 | 0.84 | CNR2 (0.46) | TSHRHTTLMNACYP3A4NFKB1 | |
| SCHEMBL7769375 | 0.84 | CNR2 (0.46) | TSHRHTTLMNACYP3A4NFKB1 | |
| SCHEMBL7769345 | 0.83 | HTT (0.40) | TSHRHTTLMNACYP3A4NFKB1 | |
| SCHEMBL7771085 | 0.80 | CAD (0.43) | TSHRHTTLMNACYP3A4NFKB1 | |
| SCHEMBL3813384 | 0.80 | TSHR (0.40) | TSHRHTTLMNACYP3A4NFKB1 | |
| SCHEMBL27762457 | 0.80 | TSHR (0.40) | TSHRHTTLMNACYP3A4NFKB1 | |
| SCHEMBL7766030 | 0.79 | HTT (0.42) | TSHRHTTLMNACYP3A4NFKB1 | |
| SCHEMBL3807501 | 0.79 | HTT (0.42) | TSHRHTTLMNACYP3A4NFKB1 | |
| SCHEMBL7766007 | 0.77 | CAD (0.34) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| SCHEMBL7771339 | 0.77 | CNR2 (0.44) | TSHRHTTLMNACYP3A4NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1077110-C | 13-substituted milbemycin 5-oxime derivatives their preparation and their use against insects and other pests | SANKYO CO (JP) | 2002-01-02 | — | — | CN | disclosed |
| EP-0765879-B1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO CO (JP) | 2001-02-14 | — | — | EP | disclosed |
| US-5861429-A | MITICIDES AND ANTHELMINTICS | SANKYO COMPANY, LIMITED (JP) | 1999-01-19 | — | — | US | disclosed |
| CN-1153177-A | 13-substituted milbemycin 5-oxime derivatives their preparation and their use against insects and other pests | SANKYO CO (JP) | 1997-07-02 | — | — | CN | disclosed |
| EP-0765879-A1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO COMPANY LIMITED (JP) | 1997-04-02 | — | — | EP | disclosed |