Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15421259 | 0.79 | ALDH1A1 (0.42) | ALDH1A1HPGDKDM4E | |
| SCHEMBL1098358 | 0.77 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2POLBKEAP1ADRA2C | |
| SCHEMBL3913097 | 0.76 | HSD17B10 (0.47) | ALDH1A1SMN1; SMN2POLBKDM4ELMNA | |
| SCHEMBL197213 | 0.75 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2POLBKEAP1NR3C2 | |
| SCHEMBL314338 | 0.74 | KIF11 (0.46) | ALDH1A1SMN1; SMN2POLBKEAP1EPHX2 | |
| SCHEMBL2896327 | 0.74 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2POLBKEAP1ADRA2C | |
| SCHEMBL29522198 | 0.72 | ALDH1A1 (0.75) | ALDH1A1SMN1; SMN2POLBKEAP1HPGD | |
| SCHEMBL1677059 | 0.72 | ALDH1A1 (0.75) | ALDH1A1SMN1; SMN2POLBKEAP1HPGD | |
| SCHEMBL1098901 | 0.71 | POLB (0.47) | ALDH1A1SMN1; SMN2POLBKEAP1EPHX2 | |
| SCHEMBL9555262 | 0.71 | CA1 (0.49) | ALDH1A1SMN1; SMN2POLBKEAP1ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0334590-B1 | 3-(Substituted)-1-carba(dethia)-3-cephems and cephalosporins and a process for production therefor | LILLY CO ELI (US) | 2001-07-04 | — | — | EP | disclosed |
| EP-0565351-B1 | Process for preparing 7-substituted-amino-3-hydroxy-3-cephem-4-protected carboxy-sulfoxide esters | LILLY CO ELI (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-0558215-B1 | Novel methods and compounds for the preparation of carbacephems | LILLY CO ELI (US) | 1999-09-15 | — | — | EP | disclosed |
| US-5700933-A | 3(2-OXAZOLIDINONE-3-YL)-2-AZETIDINONE-1-ACETIC ACID OR ESTER FOR MAKING CARBACEPHALOSPORINS ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1997-12-23 | — | — | US | disclosed |
| US-5644051-A | ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1997-07-01 | — | — | US | disclosed |
| EP-0494118-B1 | Process for 3-exomethylenecepham sulfoxide esters | LILLY CO ELI (US) | 1997-04-09 | — | — | EP | disclosed |
| US-5521307-A | Methods and compounds for the preparation of carbacephems | ELI LILLY AND COMPANY (US) | 1996-05-28 | — | — | US | disclosed |
| US-5512454-A | Enzymatic acylation of 3-hydroxymethyl cephalosporins | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0677523-A1 | 3-(substituted)-1-carba(dethia)-3-cephems and cephalosporins and a process for production therefor | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |
| EP-0667396-A1 | Enzymatic acylation of 3-hydroxymethyl cephalosporins | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-08-16 | — | — | EP | disclosed |
| US-4820832-A | Process for preparing 3-unsubstituted cephalosporins and 1-carba(dethia)cephalosporins | ELI LILLY AND COMPANY (US) | 1989-04-11 | — | — | US | disclosed |
| US-4820816-A | 3-trifuoromethylsulfonyloxy-substituted 1-carbacephalosporins as intermediates for antibiotics | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0299728-A2 | Carbonylation process for beta-lactam antibiotics | ELI LILLY AND COMPANY (US) | 1989-01-18 | — | — | EP | disclosed |
| US-4791106-A | 1-Carbacephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1988-12-13 | — | — | US | disclosed |
| US-4778884-A | REACTING TRIFLUOROMETHYLSULFONYLOXY COMPOUND WITH LITHIUM HALIDE IN APROTIC POLAR SOLVENT | PRESIDENT & FELLOWS OF HARVARD COLLEGE (US) | 1988-10-18 | — | — | US | disclosed |
| EP-0232623-A1 | 1-Carbacephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1987-08-19 | — | — | EP | disclosed |
| CN-86108961-A | 1-CARBACEPHALOSPORIN ANTIBIOTICS | — | 1987-08-05 | — | — | CN | disclosed |
| US-4673737-A | ANTIBIOTICS/ | HARVARD UNIVERSITY (US) | 1987-06-16 | — | — | US | disclosed |
| EP-0211540-A1 | Intermediates and process for antibiotics | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1987-02-25 | — | — | EP | disclosed |
| CN-86105247-A | Antibiotic intermediate and preparation method | — | 1987-02-04 | — | — | CN | disclosed |