Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5185627 | 0.95 | POLB (0.33) | POLBGAAHSP90AA1MAPK1SMN1; SMN2 | |
| SCHEMBL1661802 | 0.87 | GAA (0.40) | POLBGAAHSP90AA1MAPK1SMN1; SMN2 | |
| SCHEMBL3929573 | 0.85 | GAA (0.39) | POLBGAAHSP90AA1MAPK1SMN1; SMN2 | |
| SCHEMBL1578848 | 0.85 | GAA (0.41) | POLBGAAHSP90AA1MAPK1SMN1; SMN2 | |
| SCHEMBL29712141 | 0.75 | POLB (0.33) | POLBGAAHSP90AA1MAPK1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL175377 | 0.75 | POLB (0.37) | POLBGAAHSP90AA1MAPK1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4542337 | 0.75 | POLB (0.37) | POLBGAAHSP90AA1MAPK1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2064723 | 0.75 | POLB (0.37) | POLBGAAHSP90AA1MAPK1SMN1; SMN2 | |
| SCHEMBL29712098 | 0.74 | POLB (0.32) | POLBGAAHSP90AA1MAPK1SMN1; SMN2 | |
| SCHEMBL2868301 | 0.73 | GAA (0.38) | POLBGAAHSP90AA1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124686-A1 | REGIO-REGULAR FUNCTIONALIZED POLYMERIC PACKAGING MATERIAL | Cryovac, Inc. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-6203923-B1 | POLYMERS WITH HYDROXY, CARBOXY ACID, CARBOXY ESTER, ACETATE. AMIDE, NITRILE OR CARBONYL | CRYOVAC, INC. | 2001-03-20 | — | — | US | disclosed |
| WO-2000018579-A1 | REGIO-REGULAR FUNCTIONALIZED POLYMERIC PACKAGING MATERIAL | CRYOVAC, INC. (US) | 2000-04-06 | — | — | WO | disclosed |