Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.45 |
| ▸ | WNT3A | P56704 | 3/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5900356 | 0.98 | KMT2A (0.51) | KMT2AKDM4EMEN1LMNANAPRT | |
| SCHEMBL2601877 | 0.98 | LMNA (0.53) | KMT2AKDM4EMEN1LMNANAPRT | |
| Bromide SCHEMBL5899856 | 0.97 | LMNA (0.52) | KMT2AKDM4EMEN1LMNANAPRT | |
| Iodide SCHEMBL31327468 | 0.97 | LMNA (0.52) | KMT2AKDM4EMEN1LMNANAPRT | |
| Iodide SCHEMBL1930231 | 0.97 | LMNA (0.52) | KMT2AKDM4EMEN1LMNANAPRT | |
| Bromide SCHEMBL3894863 | 0.78 | KMT2A (0.53) | KMT2AKDM4EMEN1LMNANAPRT | |
| Iodide SCHEMBL5956032 | 0.77 | PABPC1 (0.53) | KMT2AKDM4EMEN1LMNAL3MBTL1 | |
| Bromide SCHEMBL698678 | 0.74 | KDM4E (0.79) | KMT2AKDM4EMEN1LMNACES1 | |
| Hydrochloric Acid SCHEMBL2527501 | 0.74 | KMT2A (0.73) | KMT2AKDM4EMEN1LMNACES1 | |
| Bromide SCHEMBL27941533 | 0.74 | KDM4E (0.79) | KMT2AKDM4EMEN1LMNACES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248870-B1 | OLIGO-2,6-PYRIMIDINE COMPLEXING AGENT. | NYCOMED IMAGING AS (NO) | 2001-06-19 | — | — | US | disclosed |
| US-5817774-A | Unsymmetrical complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods | STERLING WINTHROP INCORPORATION (US) | 1998-10-06 | — | — | US | disclosed |
| US-5559214-A | Unsymmetrical complexing agents and targeting immunoreagents useful in thearpeutic and diagnostic compositions and methods | STERLING WINTHROP INC. (US) | 1996-09-24 | — | — | US | disclosed |