SCHEMBL7770672

SCHEMBL7770672

C[Si](C)(C1=CC=CC1)c1ccccc1N

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.31
ALOX15 P16050 1/20 0.31
CASP1 P29466 1/20 0.31
CASP7 P55210 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5090808 0.76 CA1 (0.39)
SCHEMBL6468335 0.76 CYP3A4 (0.47) CYP3A4ALOX15CASP1CASP7SMN1; SMN2
SCHEMBL8678518 0.75
SCHEMBL61232 0.73
SCHEMBL7055264 0.73 ESR1 (0.42)
SCHEMBL9148137 0.71
SCHEMBL8468485 0.71
SCHEMBL9145112 0.71
Water SCHEMBL27702913 0.71
SCHEMBL60587 0.70 PNMT (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-8301890-A None JP disclosed
EP-0742046-B1 Organometallic compounds HOECHST AG (DE) 2001-07-25 EP disclosed
US-5808122-A Organometallic compound HOECHST AKTIENGESELLSCHAFT (DE) 1998-09-15 US disclosed
JP-H08301890-A ORGANOMETALLIC COMPOUND HOECHST AG 1996-11-19 JP disclosed
EP-0742046-A2 Organometallic compounds HOECHST AKTIENGESELLSCHAFT (DE) 1996-11-13 EP disclosed