Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 7/20 | 0.40 |
| ▸ | CASP2 | P42575 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7771583 | 1.00 | EPHX1 (0.62) | EPHX1ADRA1ATDP1KDM4EMAPK1 | |
| SCHEMBL7769387 | 0.98 | EPHX1 (0.59) | EPHX1ADRA1ATDP1KDM4EMAPK1 | |
| SCHEMBL7769323 | 0.92 | EPHX1 (0.55) | EPHX1TDP1KDM4EMAPK1HIF1A | |
| SCHEMBL7788569 | 0.85 | EPHX1 (0.82) | EPHX1TDP1KDM4EMAPK1HIF1A | |
| SCHEMBL717081 | 0.85 | EPHX1 (0.82) | EPHX1TDP1KDM4EMAPK1HIF1A | |
| SCHEMBL7788927 | 0.85 | EPHX1 (0.82) | EPHX1TDP1KDM4EMAPK1HIF1A | |
| SCHEMBL14252129 | 0.85 | EPHX1 (0.82) | EPHX1TDP1KDM4EMAPK1HIF1A | |
| SCHEMBL7788937 | 0.85 | EPHX1 (0.82) | EPHX1TDP1KDM4EMAPK1HIF1A | |
| SCHEMBL7765972 | 0.83 | EPHX1 (0.48) | EPHX1ACHE | |
| SCHEMBL7252127 | 0.82 | EPHX1 (0.77) | EPHX1TDP1KDM4EMAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765879-B1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO CO (JP) | 2001-02-14 | — | — | EP | disclosed |
| US-5861429-A | MITICIDES AND ANTHELMINTICS | SANKYO COMPANY, LIMITED (JP) | 1999-01-19 | — | — | US | disclosed |
| EP-0765879-A1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO COMPANY LIMITED (JP) | 1997-04-02 | — | — | EP | disclosed |