Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7773934 | 1.00 | SLC6A4 (0.42) | SLC6A4SMN1; SMN2LMNAL3MBTL1TDP1 | |
| SCHEMBL8071527 | 0.89 | CYP3A4 (0.49) | SLC6A4LMNAL3MBTL1SLC6A2SLC6A3 | |
| SCHEMBL8186428 | 0.89 | CYP3A4 (0.49) | SLC6A4LMNAL3MBTL1SLC6A2SLC6A3 | |
| SCHEMBL8551523 | 0.88 | CYP17A1 (0.47) | SLC6A4SMN1; SMN2LMNAL3MBTL1SLC6A2 | |
| SCHEMBL8553152 | 0.86 | KCNA5 (0.47) | SLC6A4SMN1; SMN2LMNAL3MBTL1SLC6A2 | |
| SCHEMBL8552624 | 0.86 | CYP19A1 (0.47) | SMN1; SMN2KCNA5CYP3A4 | |
| SCHEMBL8109544 | 0.86 | SMN1; SMN2 (0.44) | SLC6A4SMN1; SMN2SLC6A2SLC6A3GAA | |
| SCHEMBL8133883 | 0.84 | CYP17A1 (0.40) | SLC6A4SMN1; SMN2LMNAL3MBTL1SLC6A2 | |
| SCHEMBL24933823 | 0.83 | SLC6A4 (0.43) | SLC6A4SMN1; SMN2LMNAL3MBTL1TDP1 | |
| SCHEMBL8120393 | 0.83 | LMNA (0.47) | SLC6A4SMN1; SMN2LMNATDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115401-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| EP-1115706-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018730-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |
| WO-2000018731-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |
| EP-0984961-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998043971-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-08 | — | — | WO | disclosed |