Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8186428 | 0.88 | CYP3A4 (0.49) | KCNA5CYP1A2CYP2C19LRRK2LMNA | |
| SCHEMBL8071527 | 0.88 | CYP3A4 (0.49) | KCNA5CYP1A2CYP2C19LRRK2LMNA | |
| SCHEMBL7772046 | 0.86 | SLC6A4 (0.42) | KCNA5KMT2ALRRK2SMN1; SMN2LMNA | |
| SCHEMBL7773934 | 0.86 | SLC6A4 (0.42) | KCNA5KMT2ALRRK2SMN1; SMN2LMNA | |
| SCHEMBL8550969 | 0.84 | EPHX1 (0.46) | KCNA5SMN1; SMN2ADRB1ADRB3 | |
| SCHEMBL8555856 | 0.80 | LRRK2 (0.53) | KCNA5KMT2ALRRK2HSD17B10ADRB1 | |
| SCHEMBL8551523 | 0.80 | CYP17A1 (0.47) | ALDH1A1KMT2ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL8557113 | 0.80 | CYP51A1 (0.47) | ALDH1A1CYP1A2CYP2C9TSHRCYP2C19 | |
| SCHEMBL8118689 | 0.78 | KCNA5 (0.48) | KCNA5CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL8552624 | 0.78 | CYP19A1 (0.47) | KCNA5ALDH1A1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |